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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Classification & Labelling & PBT assessment

PBT assessment

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Administrative data

PBT assessment: overall result

PBT status:
the substance is not PBT / vPvB

L-isoleucine was determined to be readily biodegradable based on read-across from a recent GLP and OECD guideline study on L-valine (> 80% biodegradation within 28 d), in combination with an older determination of the biodegradation potential of L-isoleucine according to the Offhaus method.

Bioaccumulation of L-isoleucine can be excluded based on its low log Kow of -1.72.

L-isoleucine is not classified as carcinogenic, mutagenic, toxic for reproduction or Specific Target Organ Toxicity after repeated exposure according to Regulation EC No. 1272/2008 (CLP). L-isoleucine was determined not to be aquatic toxic based on read-across to L-valine (short-term toxicity test for fish and aquatic invertebrates) up to concentrations of 1000 mg/L.