Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

Although no tests are available that assess the aquatic toxicity of L-isoleucine to the relevant trophic levels, the aquatic toxicity of the substance can be sufficiently assessed based on the information available for the read-across substances L-valine and L-alanine. This read-across is deemed justified based on a comparison of the main factors driving environmental toxicity: pH, water solubility, log Kow and chemical reactivity (functional groups).


Based on this read-across, it can be concluded that acute toxicity to fish, aquatic invertebrates or algae is not expected to occur upon exposure to up to >1000 mg/L of L-isoleucine.


Furthermore, QSAR information based on the EpiSuite (EcoSAR) model are added to the dossier to further substantiate the low toxicity of L-isoleucine to the aquatic compartment.