Registration Dossier
Registration Dossier
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EC number: 256-181-3 | CAS number: 45021-77-0
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The EC50 (growth rate for diallyldimethylammonium chloride has been established at >100 mg/L based on 3 GLP studies on 2 different strains of unicellular green algae. The ErC10 for freshwater algae in a long-term study (96 hours) was 57 mg/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 100 mg/L
- EC10 or NOEC for freshwater algae:
- 57 mg/L
Additional information
The toxicity of diallyldimethylammonium chloride to unicellular green algae has been tested recently in 3 GLP studies on 2 recommended test species: Desmodesmus subspicatus (2 studies) and Pseudokirchneriella subcapitata (1 study).
In only one of these studies (Vreyenhof, 2009) was the EC50 for growth rate at 72 hours under 100 mg/L (91 mg/L). This value, however, was less than 10% below 100 mg/L and its upper 95% confidence limit was 100 mg/L. At 96 hours the value was 120 mg/L showing decreasing toxicity with time and supporting the upper 95% CL value.
Taking the above into account along with the LC50/fish of 420 mg/L, the EC50/daphnia of >100 mg/L and the EC0/bacteria of >1000 mg/L, the EC50 growth rate of diallyldimethylammonium chloride for unicellular green algae has been established at >100 mg/L.
At 96 hours the ErC10 for the freshwater algae Desmodesmus subspicatus was 57 mg/L.
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