Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-769-4 | CAS number: 71-91-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- data is from experimental reports
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- The purpose of the study was to evaluate the local irritating/corrosive effects on the rabbit skin following a single application of the test chemical
- GLP compliance:
- yes
Test material
- Reference substance name:
- Tetrylammonium bromide
- EC Number:
- 200-769-4
- EC Name:
- Tetrylammonium bromide
- Cas Number:
- 71-91-0
- Molecular formula:
- C8H20N.Br
- IUPAC Name:
- N,N,N-triethylethanaminium bromide
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material : Tetrylammonium bromide
- IUPAC name: N,N,N-triethylethanaminium bromide
- Molecular formula: C8 H20 N.Br
- Molecular weight: 210.157 g/mol
- Smiles notation: [N+](CC)(CC)(CC)CC.[BrH-]
- InChl : 1S/C8H20N.BrH/c1-5-9(6-2,7-3)8-4;/h5-8H2,1-4H3;1H/q+1;/p-1
- Substance type: Organic
- Physical state: Solid crystalline powder (white)
- Purity: 99.23%
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Tetrylammonium bromide- Molecular formula: C8H20N.Br- Molecular weight: 210.157 g/mol- Smiles notation: [N+](CC)(CC)(CC)CC.[BrH-]- InChl : 1S/C8H20N.BrH/c1-5-9(6-2,7-3)8-4;/h5-8H2,1-4H3;1H/q+1;/p-1- Substance type: Organic- Physical state: solid- Purity: 100.1 -100.2% based on Br-- Storage: At ambient temperature in the dark- Batch No: HH 85-83A
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Sex: Female - Source: The Broekmen Institute, Someren, The Netherlands - Age at study initiation: 2- 3 months old - Weight at study initiation: 2617- 2751 g - Housing: individually housed in metal cages with perforated floors - Diet (e.g. ad libitum): standard lab diet (100g/ day); obtained from Hope Farms - Water (e.g. ad libitum): tap water, ad libitum - Acclimation period: A quarantine period of 12 days followed by another 3 weeks of acclimation period ENVIRONMENTAL CONDITIONS - Temperature (°C): 20 - 21 degC - Humidity (%): 60 -70% (relative humidity) - Air changes (per hr): no data available - Photoperiod (hrs dark / hrs light): 12 hours ligth, 12 hours dark
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- yes
- Amount / concentration applied:
- 0.5 gm of test substance moistened with 0.5 ml of milli RO water
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- responses were scored at 60 minutes then 24, 48, 72 hours after patch removal
- Number of animals:
- 3
- Details on study design:
- TEST SITE - Area of exposure: left flank, central flank - % coverage: 6cm square patch of Metalline, mounted on a permeable tape - Type of wrap if used: flexible bandage (COBAN, 3M, USA) REMOVAL OF TEST SUBSTANCE - Washing (if done): yes - Time after start of exposure: 4 hours after exposure of the test chemicalOBSERVATION TIME POINTS(indicate if minutes, hours or days) : The exposed areas were examined for signs of erythema and edema and the responses were scored at 60 minutes then 24, 48, 72 hours after patch removalSCORING SYSTEM: - Method of calculation:The test reaults were evaluated according to the EEC criteria for classification and labelling of dangerous substances (Annex VI of the EEC Council directive 67/548/EEC as amended by Directive 83/467/EEC)
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- The skin of all 3 animals did not show any reactions.Signs of systemic intoxication were not observed.
Any other information on results incl. tables
Table 1: Primary Skin Irritation Scores for TEAB in the rabbit
Rabbit No. and Sex |
Body Weight (gm) |
Observation time after exposure period (hours) |
Erythema |
Edema |
269, Female |
2617 |
1 |
0 |
0 |
24 |
0 |
0 |
||
48 |
0 |
0 |
||
72 |
0 |
0 |
||
Subtotala)/ Mean valuec) |
|
|
0/0 |
0/0 |
271, Female |
2751 |
1 |
0 |
0 |
24 |
0 |
0 |
||
48 |
0 |
0 |
||
72 |
0 |
0 |
||
Subtotala)/ Mean valuec) |
|
|
0/0 |
0/0 |
276, Female |
2646 |
1 |
0 |
0 |
24 |
0 |
0 |
||
48 |
0 |
0 |
||
72 |
0 |
0 |
||
Subtotala)/ Mean valuec) |
|
|
0/0 |
0/0 |
Totalb)/ Mean value |
|
|
0/0 |
0/0 |
Where,
a)Subtotal = sum of 24,48,72 hours scores for each animals individually
b)Total = sum of 24, 48, 72 hours scores calculated over all animals
c)Mean value = mean score of 24,48 and 72 hours reading time
Primary Irritation Index (PII)*= 0
*- Total of 24 and 72 hours scores for erythema and edema, divided by 6
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- The skin of all 3 animals did not show any reactions.Signs of systemic intoxication were not observed.The Primary Irritation Index (PII) of the test chemical was 0.0
Based on these results and applying the EEC criteria for classification and labelling of dangerous substances (Annex VI of the EEC Council directive 67/548/EEC as amended by Directive 83/467/EEC), the test chemical need not be labelled as Skin Irritant. - Executive summary:
The test chemical was applied in a single dose to the skin of the experimental animals, each animal serving as its own control.The degree of irritation was evaluated and scored according to OECD 404 Guidelines at specific intervals.
3 young adult female New Zealand White rabbits were used for the study. One day before dose administration, the fur was removed from the central back of the rabbits by clipping, exposing an area of skin of approximately 10*10 cm. 0.5 gm of test substance moistened with 0.5 ml of milli RO water was applied on 6cm square patch of Metalline, mounted on a permeable tape.this was applied to the left flank of each animal.The right flank being covered with same dressing with the test chemical served as control.Finally the animals were wrapped in a flexible bandage. The exposure duration was 4 hours, after which the remaining test substance was gently removed using a tissue moistened with tap-water. The exposed areas were examined for signs of erythema and edema and the responses were scored at 60 minutes then 24, 48, 72 hours after patch removal. The test results were evaluated according to the EEC criteria for classification and labelling of dangerous substances (Annex VI of the EEC Council directive 67/548/EEC as amended by Directive 83/467/EEC).
The skin of all 3 animals did not show any reactions.Signs of systemic intoxication were not observed.The Primary Irritation Index (PII) of the test chemical was 0.0
Based on these results and applying the EEC criteria for classification and labelling of dangerous substances (Annex VI of the EEC Council directive 67/548/EEC as amended by Directive 83/467/EEC), the test chemical need not be labelled as Skin Irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.