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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
experimental data of read across substances
Justification for type of information:
Data for the target chemical is summarized based on the structurally similar read across chemicals.
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Qualifier:
according to
Guideline:
other: refer principle below
Principles of method if other than guideline:
WoE report is based on two hydrolysis studies as-
2. and 3.
GLP compliance:
not specified
Radiolabelling:
not specified
Analytical monitoring:
not specified
Positive controls:
not specified
Negative controls:
not specified
Transformation products:
not specified
DT50:
> 1 yr
Remarks on result:
other: 2. Other details not known
DT50:
2.91 d
Remarks on result:
other: 3. Other details not known
Details on results:
2. The half-life period of test chemical was determined to be > 1 yr. Thus, test chemical was reported to be hydrolytically stable.
3. No data available
Validity criteria fulfilled:
not specified
Conclusions:
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 2.91 days to > 1 yr, respectively. Thus, based on this half-life value, it can be concluded that the test chemical undergoes slow to negligible hydrolysis in water.

Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical.The studies are as mentioned below:

The half-life value of the test chemical was determined.The hydrolysis of the quaternary nitrogen to a tertiary amine and an alcohol is thermodynamically very unfavorable with a delta G estimated from the delta H of reaction greater than +400 kJ mole. This is predicted to be a very endothermic reaction and should occur only under conditions of very high temperature.Thus, it can be concluded that the test chemical is stable in water and has a hydrolysis half-life of > 1 yr. On the basis of this, test chemical is considered to be not hydrolysable.

In an another study, the half life of hydrolysis of test chemical was estimated by using a reported dimensionless Henry’s Law Constant of 54000, in model river 1 m deep, flowing at 1 m/sec with a wind velocity of 3 m/sec. The half life of hydrolysis of test chemical  was determined to be 2.91 days (70 hrs). The half life value indicates that the test chemical is slowly hydrolysable.

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 2.91 days to > 1 yr, respectively. Thus, based on this half-life value, it can be concluded that the test chemical undergoes slow to negligible hydrolysis in water.

Description of key information

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 2.91 days to > 1 yr, respectively. Thus, based on this half-life value, it can be concluded that the test chemical undergoes slow to negligible hydrolysis in water.

Key value for chemical safety assessment

Additional information

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical.The studies are as mentioned below:

The half-life value of the test chemical was determined.The hydrolysis of the quaternary nitrogen to a tertiary amine and an alcohol is thermodynamically very unfavorable with a delta G estimated from the delta H of reaction greater than +400 kJ mole. This is predicted to be a very endothermic reaction and should occur only under conditions of very high temperature.Thus, it can be concluded that the test chemical is stable in water and has a hydrolysis half-life of > 1 yr. On the basis of this, test chemical is considered to be not hydrolysable.

In an another study, the half life of hydrolysis of test chemical was estimated by using a reported dimensionless Henry’s Law Constant of 54000, in model river 1 m deep, flowing at 1 m/sec with a wind velocity of 3 m/sec. The half life of hydrolysis of test chemical  was determined to be 2.91 days (70 hrs). The half life value indicates that the test chemical is slowly hydrolysable.

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 2.91 days to > 1 yr, respectively. Thus, based on this half-life value, it can be concluded that the test chemical undergoes slow to negligible hydrolysis in water.