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Hydrolysis

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 2.91 days to > 1 yr, respectively. Thus, based on this half-life value, it can be concluded that the test chemical undergoes slow to negligible hydrolysis in water.

Additional information

Hydrolysis

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical.The studies are as mentioned below:

The half-life value of the test chemical was determined.The hydrolysis of the quaternary nitrogen to a tertiary amine and an alcohol is thermodynamically very unfavorable with a delta G estimated from the delta H of reaction greater than +400 kJ mole. This is predicted to be a very endothermic reaction and should occur only under conditions of very high temperature.Thus, it can be concluded that the test chemical is stable in water and has a hydrolysis half-life of > 1 yr. On the basis of this, test chemical is considered to be not hydrolysable.

In an another study, the half life of hydrolysis of test chemical was estimated by using a reported dimensionless Henry’s Law Constant of 54000, in model river 1 m deep, flowing at 1 m/sec with a wind velocity of 3 m/sec. The half life of hydrolysis of test chemical  was determined to be 2.91 days (70 hrs). The half life value indicates that the test chemical is slowly hydrolysable.

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 2.91 days to > 1 yr, respectively. Thus, based on this half-life value, it can be concluded that the test chemical undergoes slow to negligible hydrolysis in water.