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EC number: 200-769-4
CAS number: 71-91-0
No clinical effects were observed. Body weight development of the treated group was not different from that of the control group. During the induction phase, treated animals showed slight to well-defined erythema and very slight oedema at the treated skin area.
The skin sensitization study oftest chemicalwas performed byBuehler test using30 femalePirbrightalbinoguinea pigs in treated group and 10 in control group. Doses were selected on the bases of preliminary study using 6 animals.
In induction phase, induction given on day 1, using 4 % concentration inwaterby topical application as2 x 2 cm cellulose patch to the clipped skin of the left flank. The patch was covered with an occlusive dressing for 6 hours and removed afterwards. The second induction given on day 8 and third on day 15 using same procedure on day first. During the induction phase, the skin sites were
examined for local effects 24 hours after each treatment
In challenge phase, on day 29 test substance 1% concentration in same vehicle appliedon a 2 x 2 cm patch to the clipped skin of the right flank and covered with an occlusive dressing for 6 hour and evaluated 24 and 48hr after removal of occlusive dressing .All animals were observed daily for signs of systemic toxicity. Body weights were recorded on days 1 and 31.No skin sensitizing reaction observed after challenge applicationalso no clinical effects were observed. Body weight development of the treated group was not different from that of the control group. During the induction phase, treated animals showed slight to well-defined erythema and very slight oedema at the treated skin area.
After challenge, skin reactions were observed neither in the treated group nor in the control group.Hence the test chemicalwas considered to be not skin sensitizing in guinea pig.
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