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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
For justification of read across please refer to section 13.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
No information
Author:
Gaillard D and Derache R
Year:
1965
Bibliographic source:
Trav Soc. Pharm . Montpellier 25, 51-62 (1965)
Reference Type:
secondary source
Title:
No information
Author:
Gaillard D and Derache R
Year:
1982
Bibliographic source:
Patty's Ind. Hyg. Toxicol. Vol. 2c, 3rd ed., 4591-4594 (1982)

Materials and methods

Objective of study:
distribution
Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Pentan-1-ol
EC Number:
200-752-1
EC Name:
Pentan-1-ol
Cas Number:
71-41-0
Molecular formula:
C5H12O
IUPAC Name:
pentan-1-ol
Details on test material:
- Name of test material (as cited in study report): Pentan-1-ol

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Duration and frequency of treatment / exposure:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
2000 mg/kg bw
No. of animals per sex per dose / concentration:
no data
Control animals:
not specified
Details on dosing and sampling:
PHARMACOKINETIC STUDY (Absorption, distribution, excretion)
- Tissues and body fluids sampled: urine, blood
- Time and frequency of sampling: up to 8 h

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on excretion:
Blood: 6.7 mg/100 mL at 15 min, 12 mg/100 mL at 30 min, 12 mg/100 mL at 1 h, 7 mg/100 mL at 1.5 h, 4.6 mg/100 mL at 2 h, 2.2 mg/100 mL at 4 h and 2 mg/100 mL at 8 h.
Urine: no alcohol detected

Applicant's summary and conclusion