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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

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Description of key information

The acute toxicity of the test substance pentanol, branchend and linear was determined in a static 48 hours GLP study with Daphnia magna according to OECD 202 (BASF 2011). The EC50 value of this substance was determined to be nominal greater than 120 mg/L. In conclusion, the 48h-EC50 value of the test substance and of the read across category members was determined to be greater than 100 mg/L. The EC50 value determined with the read-across substance 3-methylbutan-1-ol was chosen as “key value” and used for PNEC derivation, reflecting a worst-case scenario.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
255 mg/L

Additional information

The acute toxicity of the test substance pentanol, branchend and linear was determined in a static 48 hours GLP study with Daphnia magna according to OECD 202 (BASF 2011). The EC50 value of this substance was determined to be nominal greater than 120 mg/L.

The acute toxicity of the test substance pentanol, branchend and linear was determined in a static 48 hours GLP study with Daphnia magna according to OECD 202 (BASF 2011). The nominal concentration was 120 mg/L. The analytically determined concentrations of the test substance in the test solutions were determined to be within ± 20 % of the nominal concentrations. The number of the organisms per vessel was 5 and the number of vessels per concentration/control was 4. The EC50 value of this substance was determined to be nominal greater than 120 mg/L.

In addition, a read across category approach was done to the other category members.

In the acute immobilization test with Daphnia magna (STRAUS), the effects of the surrogate test substance with a nominal loading of 0 0, 15.625, 31.3, 62.5, 125, 250, and 500 mg test item/L and a control (0 mg test item/L) were determined according to Regulation (EC) No 79/831/C2 under non GLP conditions (BASF 1990). No concentrations were analytically measured. The mobility of the Daphnia was determined in a static 48-hour test by visual observation after 3, 6, 24 and 48 hours. The 48h-EC50 value was determined to be nominal 341 mg test item/L.

In addition, the acute toxicity of the surrogate test substance 2-methylbutan-1-ol on aquatic invertebrates was investigated under GLP conditions according to OECD 202 (BASF 2011). The 48h-EC50 value was determined to be greater than 173 mg/L (value based on measured concentration).

Supplementary the acute toxicity of the surrogate test substance 3-methylbutan-1-ol to Daphnia magna was assessed according to DIN 38412 L11 (BASF 1990). The 48 h-EC50 value was determined to be nominal 255 mg test item/L.

In conclusion, the 48h-EC50 value of the test substance and of the read across category members was determined to be greater than 100 mg/L. The EC50 value determined with the read-across substance 3-methylbutan-1-ol was chosen as “key value” and used for PNEC derivation, reflecting a worst-case scenario.