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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vitro / ex vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
A read-across justification is provided in the IUCLID chapter "assessment reports"

Data source

Reference
Reference Type:
review article or handbook
Title:
European Interlaboratory Evaluation of an in Vitro Ocular Irritation Model (Skin2TM Model ZKll00) Using 18 Chemicals and Formulated Products
Author:
Joller PW et al.
Year:
1994
Bibliographic source:
Alternatives to Animal Testing. New Ways in the Biomedical Sciences, Trends and Progress. Reinhardt, C.A. (ed.). VCH, Weinheim.

Materials and methods

Principles of method if other than guideline:
Testing of chemicals in an in vitro Ocular Irritation Model (Skin2TM Model ZK1100) in an interlaboratory study
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Pentan-1-ol
EC Number:
200-752-1
EC Name:
Pentan-1-ol
Cas Number:
71-41-0
Molecular formula:
C5H12O
IUPAC Name:
pentan-1-ol
Details on test material:
- Name of test material (as cited in study report): 1-Pentanol

Test animals / tissue source

Species:
other: Skin2TM Model ZK 110 (Advanced Tissue Sciences Inc., La Jolla, CA)
Strain:
not specified

Test system

Vehicle:
other: medium
Controls:
yes, concurrent no treatment
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2 ml
- Concentration (if solution): 0.1, 0.3, 1.0, 3.0, 10.0%
Duration of treatment / exposure:
one application
Observation period (in vivo):
not applicable
Number of animals or in vitro replicates:
not applicable
Details on study design:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no


SCORING SYSTEM:
acc. to in the Journal officièl de la République Française (24.10.84)

Results and discussion

Any other information on results incl. tables

Data of LDH and PGE2 were not given, although stated that PGE2 values correspond to values of irritancy.

Applicant's summary and conclusion