Registration Dossier

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Study period:
1959
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions
Justification for type of information:
A read-across justification is provided in the IUCLID chapter "assessment reports"

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1959
Report date:
1959

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Dermal irritation of test material in rabbits was determined.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methylbutan-1-ol
EC Number:
205-289-9
EC Name:
2-methylbutan-1-ol
Cas Number:
137-32-6
Molecular formula:
C5H12O
IUPAC Name:
2-methylbutan-1-ol
Details on test material:
No additional information available.

Test animals

Species:
rabbit
Strain:
other: albino
Details on test animals or test system and environmental conditions:
No additional information provided

Test system

Type of coverage:
open
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
0.01 ml
Duration of treatment / exposure:
24 hour exposure period.
Observation period:
Application site scored at end of exposure period for:
Necrosis
Swelling
Redness
Injection of capillaries
Number of animals:
5 rabbits
Details on study design:
Test material, 0.01 ml, was applied to shaved rabbit abdomen. The application was unoccluded and examined after 24 hours for signs of irritation.

Results and discussion

In vivo

Results
Irritation parameter:
other: No scores available
Remarks on result:
other: Minimal irritation was observed in 2 of 5 rabbits treated with 0.01 mL test material. The remaining three rabbits exhibited no evidence of dermal irritation.
Irritant / corrosive response data:
The uncovered application of 0.01mL amounts of undiluted methyl butanol to the clipped skin of the rabbit belly caused no response on three animals and minimal capillary injection on the other two.
Other effects:
No other effects reported.

Any other information on results incl. tables

No additional information available.

Applicant's summary and conclusion

Conclusions:
At the dose examined, minimal dermal irritation was observed in rabbits.
Executive summary:

The dermal irritation of 2 -methylbutanol was examined. The uncovered application of 0.01 mL amounts of undiluted methyl butanol to the clipped skin of the rabbit belly caused no response on three animals and minimal capillary injection on the other two.