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Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
A read-across justification is provided in the IUCLID chapter "assessment reports"

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Induction of human skin sensitization to ethanol
Author:
Stotts J and Ely WJ
Year:
1977
Bibliographic source:
Journal of Investigative Dermatology, 69, 219-222
Reference Type:
secondary source
Title:
No information
Author:
RIFM
Year:
2009
Bibliographic source:
RIFM database

Materials and methods

Type of sensitisation studied:
skin
Study type:
case report
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Rechallenge of 2 patients
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Pentan-1-ol
EC Number:
200-752-1
EC Name:
Pentan-1-ol
Cas Number:
71-41-0
Molecular formula:
C5H12O
IUPAC Name:
pentan-1-ol
Details on test material:
- Name of test material (as cited in study report): 1-pentanol

Method

Type of population:
general
Subjects:
- Number of subjects exposed: 2
Clinical history:
- History of allergy or casuistics for study subject or populations: one sensitized during a human patch test to ethanol; one to acetaldehyde during a dose range finder for a non-irritant concentration
Route of administration:
dermal

Results and discussion

Results of examinations:
RESULT OF CASE REPORT:
Positive reactions to pentanol were observed in both subjects after testing with 10% (subject 1) and 20% (subject 2) pentanol. Both reacted also to ethanol, propanol, 2-propanol, and acetaldehyde.

Applicant's summary and conclusion