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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

The following remarks on the toxicokinetics of ITC 288/S are based on physico-chemical properties of the compound and on toxicological data. Experimental toxicokinetic studies were not performed .



The low toxicity of the substance when administered orally compared with the greater toxicity when 

administered by the intraperitoneal route in the micronucleus study suggests that the substance is poorly 

absorbed from the gastro- intestinal tract. The poor lipid solubility of the substance indicates 

that dermal absorption will be low. 



There is no experimental evidence to indicate distribution of any absorbed substance 

but the low fat solubility and log Pow value suggest that bioaccumulation is unlikely. The substance was shown to induce contact sensitisation in a guinea pig study so it, 

presumably, can become bound to proteins.



An in-vitro chromosome aberration study showed some evidence of increased cytotoxicity 

in the presence of S9 (an hepatic metabolising enzyme broth). This may indicate that the substance has potential to be biotransformed by microsomal enzymes but there is no 

other experimental evidence to support this. 



Again, there is no evidence to indicate a route of excretion for this substance but it's water solubility 

is such that excretion of unchanged parent substance could occur by biliary or renal routes. Presumably, 

any metabolites would be similarly water soluble. In view of the possible potential of the substance 

to become protein bound, excretion in the bile might be anticipated. The parent substance could not 

be eliminated via the lungs in expired air because it is non-volatile.