Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

basic toxicokinetics
Type of information:
other: Toxicokinetics assessment
Adequacy of study:
weight of evidence
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Based on the known physico-chemical properties and the available toxicologic studies, a justified assessment of the toxicokinetic and biotransformational properties of ITC 288/S could be made, therefore an in vivo toxicokinetic study is at present not an urgent requirement.

Data source

Reference Type:
other: Toxicocinetics assessment

Materials and methods

Objective of study:
other: Assessment of toxicokinetic behaviour
Test guideline
no guideline followed
Principles of method if other than guideline:
Assessment of Toxicokinetics

Test material

Constituent 1
Constituent 2
Chemical structure
Reference substance name:
A mixture of: tetrasodium-phosphonoethane-1,2-dicarboxylate; hexasodium-phosphonobutane-1,2,3,4-tetracarboxylate
EC Number:
EC Name:
A mixture of: tetrasodium-phosphonoethane-1,2-dicarboxylate; hexasodium-phosphonobutane-1,2,3,4-tetracarboxylate
Cas Number:
Molecular formula:
Constituent 1 (tetrasodium phosphonoethane-1,2-dicarboxylate): Hill formula: C4H3Na4O7P CAS formula: C4 H7 O7 P .4Na Constituent 2 (hexasodium-phosphonobutane-1,2,3,4-tetracarboxylate): Hill formula: C8H5Na6O11P CAS formula: C8 H11 O7 P .6Na
Reaction mass of tetrasodium phosphonoethane-1,2-dicarboxylate and hexasodium-phosphonobutane-1,2,3,4-tetracarboxylate
Specific details on test material used for the study:
Purity of the test material is based on the phosphonate composition, with no direct measure of % sodium. ITC 288 is not the "Reaction mass of tetrasodium-phosphonoethane-1,2-dicarboxylate and hexasodium-phosphonobutane-1,2,3,4--tetracarboxylate" (EC 410-800-5) rather the substance "Reaction mass of trisodium-phosphonoethane-1,2-dicarboxylate and pentasodium-phosphonobutane-1,2,3,4--tetracarboxylate" (EC 701-079-0) as demonstrated by the manufacturing specs reported in Section 1.2, legal entity composition.

Results and discussion

Applicant's summary and conclusion