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EC number: 209-876-0
CAS number: 596-03-2
Primary eye irritation potential was evaluated for the test chemical erythrosine. 0.2mL of 10% aqueous solution was applied in the conjuctival sac of one eye of a group of at least 6 albino rabbits. The application was repeated twice daily, 5 days per week for 4 weeks.
One hour after each application the eyes were examined for evidence of staining and irritation was scored according to Draize.
Three days after the last application, two animals of each group (erythrosine colour and erythrosine lake) were killed; upper lids were taken for microscopic examination. Eyeballs and posterior parts were examined grossly for evidence of staining or other abnormalities. Erythrosine colour caused intense colouring of the iris and moderate conjunctival irritation. Staining lasted from 2 to 7 days. Erythrosine lake did not cause severe eye irritation but resulted in spotty staining in some animals and very slight but uniform staining in other animals.
Therefore, Erythrosine (16423-68-0) was assessed to be not irritating to the eyes of rabbits when treated for 4 weeks.
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