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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
20/8/2016-20/8/2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: lab data
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
The particle size distribution of test item 4’,5’-dibromo-3’,6’-dihydroxyspiro[isobenzofuran-1(3H),9’-[9H]xanthene]-3-one (CAS No. 596-03-2 )was determined by granulometric analysis with rotap sieve shaker.
GLP compliance:
no
Type of method:
sieving
Type of distribution:
counted distribution
Percentile:
D50
Remarks on result:
other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.
No.:
#1
Size:
150 µm
Distribution:
10.02 %
Remarks on result:
other: no additional details mentioned
No.:
#2
Size:
106 µm
Distribution:
62.88 %
Remarks on result:
other: no additional details mentioned
No.:
#3
Size:
75 µm
Distribution:
11.82 %
Remarks on result:
other: no additional details mentioned
No.:
#4
Size:
53 µm
Distribution:
9.48 %
Remarks on result:
other: no additional details mentioned
No.:
#5
Size:
25 µm
Distribution:
5.77 %
Remarks on result:
other: no additional details mentioned

Table 1: Observation Table

Amount of test item weighed (g) = 9.567 g        

Test item run time (min) =10 min

 

Sieve sizes(in microns)

Weight of petridishes (g)

Weight of petridishes +

test item (g)

Test item quantity retained after sieving (g)

Percentage (%) of test item in each sieve*

150 microns

53.915

54.36

0.871

10.02 %

106 microns

37.327

42..790

5.463

62.88%

75 microns

44.481

45.508

1.027

11.82 %

53 microns

48.731

49.555

0.824

9.48 %

25 microns

41.9634

42.136

0.502

5.77%

10 microns

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*Percentage of test item =   Test item retained on each sieve after sieving X 100

                                                   Total amount of test item retained on sieve

Conclusions:
The particle size distribution of test item 4’,5’-dibromo-3’,6’-dihydroxyspiro[isobenzofuran-1(3H),9’-[9H]xanthene]-3-one (CAS No. 596-03-2 )was determined by granulometric analysis with rotap sieve shaker. The particle size distribution was found to be in the range of 150 micron to 25 micron.
Executive summary:

The particle size distribution of test item 4’,5’-dibromo-3’,6’-dihydroxyspiro[isobenzofuran-1(3H),9’-[9H]xanthene]-3-one (CAS No. 596-03-2 ) was determined by granulometric analysis with rotap sieve shaker. The particle size distribution was found to be in the range of 150 micron to 25 micron.

Description of key information

The particle size distribution of test item 4’,5’-dibromo-3’,6’-dihydroxyspiro[isobenzofuran-1(3H),9’-[9H]xanthene]-3-one (CAS No. 596-03-2 ) was determined by granulometric analysis with rotap sieve shaker. The particle size distribution was found to be in the range of 150 micron to 25 micron.

Additional information

The particle size distribution of test item 4’,5’-dibromo-3’,6’-dihydroxyspiro[isobenzofuran-1(3H),9’-[9H]xanthene]-3-one (CAS No. 596-03-2 ) was determined by granulometric analysis with rotap sieve shaker. The particle size distribution was found to be in the range of 150 micron to 25 micron.