Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 209-876-0 | CAS number: 596-03-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer-reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- A Review of the Toxicity of Twelve Fluorescent Dyes Used for Water Tracing
- Author:
- P.L. Smart
- Year:
- 1 984
- Bibliographic source:
- The NSS Bulletin, Volume 46 Number 2: 21-33 - October 1984, A publication of the National Speleological Society
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as per mentioned below
- Principles of method if other than guideline:
- Study is conducted to check the LD50 of Sodium fluorescein after oral administration in rat
- GLP compliance:
- not specified
- Test type:
- other: no data
- Limit test:
- no
Test material
- Reference substance name:
- Disodium 2-(3-oxo-6-oxidoxanthen-9-yl)benzoate
- EC Number:
- 208-253-0
- EC Name:
- Disodium 2-(3-oxo-6-oxidoxanthen-9-yl)benzoate
- Cas Number:
- 518-47-8
- Molecular formula:
- C20H12O5.2Na
- IUPAC Name:
- disodium 3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-3',6'-diolate
- Test material form:
- other: Solid
- Details on test material:
- - Name of test material (IUPAC name): disodium 2-(3-oxo-6-oxidoxanthen-9-yl)benzoate- Common name: Fluorescein sodium- Molecular formula: C20H10Na2O5- Molecular weight:376.274 g/mol- Smiles notation: c1(c2c(oc3c1ccc(c3)[O-])cc(=O)cc2)c1c(cccc1)C(=O)[O-].[Na+].[Na+]- InChl: 1S/C20H12O5.2Na/c21-11-5-7-15-17(9-11)25-18-10-12(22)6-8-16(18)19(15)13-3-1-2-4-14(13)20(23)24;;/h1-10,21H,(H,23,24);;/q;2*+1/p-2- Substance type: Organic
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- No data available
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- Duration of observation period following administration: 14 days (or other?): 14 days
- Statistics:
- Probit analysis by method of Finney
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 6 720 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality
- Mortality:
- No data
- Clinical signs:
- other: No data
- Gross pathology:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- LD50 was considered to be 6720 mg/kg bw when rats were treated with Sodium fluorescein orally.
- Executive summary:
Ina acute oral toxicity study, rat were treated with Sodium fluorescein the concentration of 6720 mg/kg bw. 50 % mortality was observed in treated rats at 6720 mg/kg bw. Therefore, LD50 was considered to be 6720 mg/kg bw when rats were treated with Sodium fluorescein orally.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
