Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Toxicity to reproduction

Currently viewing:

Administrative data

Endpoint:
toxicity to reproduction
Remarks:
other: QSAR and read-across
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report date:
2016

Materials and methods

Principles of method if other than guideline:
OASIS TIMES receptor-mediated models and QSAR Toolbox
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-Propenenitrile, reaction products with 1,3-benzenedimethanamine
EC Number:
292-054-9
EC Name:
2-Propenenitrile, reaction products with 1,3-benzenedimethanamine
Cas Number:
90530-16-8
IUPAC Name:
2-Propenenitrile, reaction products with 1,3-benzenedimethanamine

Results and discussion

Results: P0 (first parental generation)

Effect levels (P0)

Dose descriptor:
NOAEL
Based on:
not specified
Remarks:
no data
Sex:
male/female
Remarks on result:
not measured/tested
Remarks:
no NOAEL identified Generation: QSAR and read-across prediction (migrated information)

Results: P1 (second parental generation)

Effect levels (P1)

Dose descriptor:
other: QSAR
Remarks:
QSAR
Basis for effect level:
other: QSAR test
Remarks on result:
not measured/tested
Remarks:
QSAR test

Results: F1 generation

Effect levels (F1)

Dose descriptor:
other: QSAR
Remarks:
QSAR
Remarks on result:
not measured/tested
Remarks:
QSAR

Results: F2 generation

Effect levels (F2)

Dose descriptor:
other: QSAR
Remarks:
QSAR
Remarks on result:
not measured/tested
Remarks:
QSAR

Overall reproductive toxicity

Reproductive effects observed:
not specified

Any other information on results incl. tables

No NOAEL identified.

Applicant's summary and conclusion

Conclusions:
It is not classifed as toxicity to reproduction.
Executive summary:

·        TIMES Androgen and Estrogen Binding Affinityv.03modelsare used;

·        The models are focused on the direct interactions of chemicals with the androgen and estrogen receptors (AR and ER) - that is, AR and ER binding mediated endocrine disruptions. These interactions are considered as primary events that trigger the ultimate biological responses;

2-Propenenitrile, reaction products with 1,3-benzenedimethanamineincluding constituents MXDA, A, B, C and D is predicted as not capable of eliciting interaction with androgen or estrogen receptors.