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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report Date:
2016

Materials and methods

Principles of method if other than guideline:
TIMES AMES model predictions and Toolbox read-across analyses
GLP compliance:
no
Type of assay:
bacterial reverse mutation assay

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Test results
Species / strain:
not specified
Metabolic activation:
not specified
Genotoxicity:
negative
Remarks:
QSAR prediction
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Remarks on result:
other: other: QSAR
Remarks:
Migrated from field 'Test system'.

Any other information on results incl. tables

Based on the experimental data for structural analogues, TIMES AMES model predictions and Toolbox read-across analyses, the UVCB 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine is ultimately predicted as in vitro Ames negative, i.e. not capable of eliciting mutagenicity.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative Not classified as mutagen.

Not classified as mutagen.
Executive summary:

Based on the experimental data for structural analogues, TIMES AMES model predictions and Toolbox read-across analyses, theUVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamineis ultimately predicted as in vitro Ames negative, i.e. not capable of eliciting mutagenicity.