Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 292-054-9 | CAS number: 90530-16-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation / corrosion
- Remarks:
- other: QSAR, read-across
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Principles of method if other than guideline:
- TIMES Skin irritation/corrosion predictions and QSAR Toolbox read-across predictions
- GLP compliance:
- no
- Irritation parameter:
- other: QSAR, read-across
- Basis:
- other: QSAR, read-across
- Remarks on result:
- other: QSAR and read-across
- Irritant / corrosive response data:
- • The UVCB 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine is classified as Skin Corrosive Category 1 based on the predictions of constituents A and C.
- Interpretation of results:
- Category 1 (corrosive)
- Remarks:
- Migrated information H314 Criteria used for interpretation of results: EU
- Conclusions:
- The UVCB 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine is classified as Skin Corrosive Category 1 based on the predictions of constituents A and C. (H314)
- Executive summary:
· The constituents of the UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamineare predicted by using TIMES Skin irritation/corrosion model and Toolbox read-across analysis namely:
- ConstituentsMXDA, A and C:Corrosive to skin;
- Constituents B and D:Irritating to skin;
- Constituent E:Non-irritating/corrosive to skin.
· The predictions results are considered reliable:
1) they belong to the TIMES model's and Toolbox read-across prediction applicability domains.
2) they are supported by expert judgment.
· The UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamineis classified asSkin Corrosive Category 1based on the predictions of constituents A and C.
Reference
· The constituents of the UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamineare predicted by using TIMES Skin irritation/corrosion model and Toolbox read-across analysis namely:
- ConstituentsMXDA, A and C:Corrosive to skin;
- Constituents B and D:Irritating to skin;
- Constituent E:Non-irritating/corrosive to skin.
· The predictions results are considered reliable:
1) they belong to the TIMES model's and Toolbox read-across prediction applicability domains.
2) they are supported by expert judgment.
· The UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamineis classified asSkin Corrosive Category 1based on the predictions of constituents A and C.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation
- Remarks:
- other: QSAR, read-across
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Principles of method if other than guideline:
- • TIMES modeling approach (Eye irritation/corrosion)
• Toolbox 3.3 read-across analysis - GLP compliance:
- no
- Irritation parameter:
- other: QSAR, read-across
- Basis:
- other: QSAR, read-across
- Remarks on result:
- other: QSAR, read-across
- Interpretation of results:
- Category I
- Remarks:
- Migrated information H318 Criteria used for interpretation of results: EU
- Conclusions:
- The UVCB 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine is classified in hazard Category 1 (Eye Dam 1) based on the predictions of constituents A and C.
- Executive summary:
· 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine constituents are predicted by using TIMES Eye irritationmodel and Toolbox Read-across byapplying worst case scenario,namely:
- ConstituentsMXDA, A and C:Corrosive to eye;
- Constituents B and D:Irritating to eye;
- Constituent E:Non-irritating/corrosive to eye.
· The predictions results are considered reliable:
1) they belong to the TIMES model's and Read-across prediction applicability domains
2) they are supported by expert judgment.
· The UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamine is classified in hazard Category 1 (Eye Dam 1)based on the predictions of constituents A and C.
Reference
Read-across and QSAR prediction:
· 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine constituents are predicted by using TIMES Eye irritationmodel and Toolbox Read-across byapplying worst case scenario,namely:
- ConstituentsMXDA, A and C:Corrosive to eye;
- Constituents B and D:Irritating to eye;
- Constituent E:Non-irritating/corrosive to eye.
· The predictions results are considered reliable:
1) they belong to the TIMES model's and Read-across prediction applicability domains
2) they are supported by expert judgment.
· The UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamine isclassified inhazard Category 1 (Eye Dam 1)based on the predictions of constituents A and C.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin corrosion category 1 ( H314)
Justification for selection of eye irritation endpoint:
Eye corrosion category 1 ( H318)
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Skin corrosion category 1 ( H318)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
