Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation / corrosion
Remarks:
other: QSAR, read-across
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6
Principles of method if other than guideline:
TIMES Skin irritation/corrosion predictions and QSAR Toolbox read-across predictions
GLP compliance:
no
Irritation parameter:
other: QSAR, read-across
Basis:
other: QSAR, read-across
Remarks on result:
other: QSAR and read-across
Irritant / corrosive response data:
• The UVCB 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine is classified as Skin Corrosive Category 1 based on the predictions of constituents A and C.

·        The constituents of the UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamineare predicted by using TIMES Skin irritation/corrosion model and Toolbox read-across analysis namely:

-       ConstituentsMXDA, A and C:Corrosive to skin;

-       Constituents B and D:Irritating to skin;

-       Constituent E:Non-irritating/corrosive to skin.

·        The predictions results are considered reliable:

1) they belong to the TIMES model's and Toolbox read-across prediction applicability domains.

2) they are supported by expert judgment.

·                      The UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamineis classified asSkin Corrosive Category 1based on the predictions of constituents A and C.

Interpretation of results:
Category 1 (corrosive)
Remarks:
Migrated information H314 Criteria used for interpretation of results: EU
Conclusions:
The UVCB 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine is classified as Skin Corrosive Category 1 based on the predictions of constituents A and C. (H314)
Executive summary:

·        The constituents of the UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamineare predicted by using TIMES Skin irritation/corrosion model and Toolbox read-across analysis namely:

-       ConstituentsMXDA, A and C:Corrosive to skin;

-       Constituents B and D:Irritating to skin;

-       Constituent E:Non-irritating/corrosive to skin.

·        The predictions results are considered reliable:

1) they belong to the TIMES model's and Toolbox read-across prediction applicability domains.

2) they are supported by expert judgment.

·                      The UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamineis classified asSkin Corrosive Category 1based on the predictions of constituents A and C.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation
Remarks:
other: QSAR, read-across
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6
Principles of method if other than guideline:
• TIMES modeling approach (Eye irritation/corrosion)
• Toolbox 3.3 read-across analysis
GLP compliance:
no
Irritation parameter:
other: QSAR, read-across
Basis:
other: QSAR, read-across
Remarks on result:
other: QSAR, read-across

Read-across and QSAR prediction:

·        2-Propenenitrile, reaction products with 1,3-benzenedimethanamine constituents are predicted by using TIMES Eye irritationmodel and Toolbox Read-across byapplying worst case scenario,namely:

-       ConstituentsMXDA, A and C:Corrosive to eye;

-       Constituents B and D:Irritating to eye;

-       Constituent E:Non-irritating/corrosive to eye.

·        The predictions results are considered reliable:

1) they belong to the TIMES model's and Read-across prediction applicability domains

2) they are supported by expert judgment.

·        The UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamine isclassified inhazard Category 1 (Eye Dam 1)based on the predictions of constituents A and C.

Interpretation of results:
Category I
Remarks:
Migrated information H318 Criteria used for interpretation of results: EU
Conclusions:
The UVCB 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine is classified in hazard Category 1 (Eye Dam 1) based on the predictions of constituents A and C.
Executive summary:

·        2-Propenenitrile, reaction products with 1,3-benzenedimethanamine constituents are predicted by using TIMES Eye irritationmodel and Toolbox Read-across byapplying worst case scenario,namely:

-       ConstituentsMXDA, A and C:Corrosive to eye;

-       Constituents B and D:Irritating to eye;

-       Constituent E:Non-irritating/corrosive to eye.

·        The predictions results are considered reliable:

1) they belong to the TIMES model's and Read-across prediction applicability domains

2) they are supported by expert judgment.

·        The UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamine is classified in hazard Category 1 (Eye Dam 1)based on the predictions of constituents A and C.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Justification for selection of skin irritation / corrosion endpoint:
Skin corrosion category 1 ( H314)

Justification for selection of eye irritation endpoint:
Eye corrosion category 1 ( H318)

Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: corrosive

Justification for classification or non-classification

Skin corrosion category 1 ( H318)