Registration Dossier

Administrative data

Endpoint:
skin irritation / corrosion
Remarks:
other: QSAR, read-across
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report Date:
2016

Materials and methods

Principles of method if other than guideline:
TIMES Skin irritation/corrosion predictions and QSAR Toolbox read-across predictions
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

In vivo

Results
Irritation parameter:
other: QSAR, read-across
Basis:
other: QSAR, read-across
Remarks on result:
other: QSAR and read-across
Irritant / corrosive response data:
• The UVCB 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine is classified as Skin Corrosive Category 1 based on the predictions of constituents A and C.

Any other information on results incl. tables

·        The constituents of the UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamineare predicted by using TIMES Skin irritation/corrosion model and Toolbox read-across analysis namely:

-       ConstituentsMXDA, A and C:Corrosive to skin;

-       Constituents B and D:Irritating to skin;

-       Constituent E:Non-irritating/corrosive to skin.

·        The predictions results are considered reliable:

1) they belong to the TIMES model's and Toolbox read-across prediction applicability domains.

2) they are supported by expert judgment.

·                      The UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamineis classified asSkin Corrosive Category 1based on the predictions of constituents A and C.

Applicant's summary and conclusion

Interpretation of results:
Category 1 (corrosive)
Remarks:
Migrated information H314 Criteria used for interpretation of results: EU
Conclusions:
The UVCB 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine is classified as Skin Corrosive Category 1 based on the predictions of constituents A and C. (H314)
Executive summary:

·        The constituents of the UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamineare predicted by using TIMES Skin irritation/corrosion model and Toolbox read-across analysis namely:

-       ConstituentsMXDA, A and C:Corrosive to skin;

-       Constituents B and D:Irritating to skin;

-       Constituent E:Non-irritating/corrosive to skin.

·        The predictions results are considered reliable:

1) they belong to the TIMES model's and Toolbox read-across prediction applicability domains.

2) they are supported by expert judgment.

·                      The UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamineis classified asSkin Corrosive Category 1based on the predictions of constituents A and C.