Registration Dossier

Administrative data

Endpoint:
eye irritation
Remarks:
other: QSAR, read-across
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report Date:
2016

Materials and methods

Principles of method if other than guideline:
• TIMES modeling approach (Eye irritation/corrosion)
• Toolbox 3.3 read-across analysis
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

In vivo

Results
Irritation parameter:
other: QSAR, read-across
Basis:
other: QSAR, read-across
Remarks on result:
other: QSAR, read-across

Any other information on results incl. tables

Read-across and QSAR prediction:

·        2-Propenenitrile, reaction products with 1,3-benzenedimethanamine constituents are predicted by using TIMES Eye irritationmodel and Toolbox Read-across byapplying worst case scenario,namely:

-       ConstituentsMXDA, A and C:Corrosive to eye;

-       Constituents B and D:Irritating to eye;

-       Constituent E:Non-irritating/corrosive to eye.

·        The predictions results are considered reliable:

1) they belong to the TIMES model's and Read-across prediction applicability domains

2) they are supported by expert judgment.

·        The UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamine isclassified inhazard Category 1 (Eye Dam 1)based on the predictions of constituents A and C.

Applicant's summary and conclusion

Interpretation of results:
Category I
Remarks:
Migrated information H318 Criteria used for interpretation of results: EU
Conclusions:
The UVCB 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine is classified in hazard Category 1 (Eye Dam 1) based on the predictions of constituents A and C.
Executive summary:

·        2-Propenenitrile, reaction products with 1,3-benzenedimethanamine constituents are predicted by using TIMES Eye irritationmodel and Toolbox Read-across byapplying worst case scenario,namely:

-       ConstituentsMXDA, A and C:Corrosive to eye;

-       Constituents B and D:Irritating to eye;

-       Constituent E:Non-irritating/corrosive to eye.

·        The predictions results are considered reliable:

1) they belong to the TIMES model's and Read-across prediction applicability domains

2) they are supported by expert judgment.

·        The UVCB2-Propenenitrile, reaction products with 1,3-benzenedimethanamine is classified in hazard Category 1 (Eye Dam 1)based on the predictions of constituents A and C.