Registration Dossier
Registration Dossier
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EC number: 279-420-3 | CAS number: 80206-82-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Method: other: in house procedure
- GLP compliance:
- yes
- Test type:
- other: LD50
- Limit test:
- no
Test material
- Reference substance name:
- Alcohols, C12-14
- EC Number:
- 279-420-3
- EC Name:
- Alcohols, C12-14
- Cas Number:
- 80206-82-2
- Molecular formula:
- C13H28O
- IUPAC Name:
- Alcohols, C12-14
- Details on test material:
- Tradename Lorol Spezial type 70 C12-14 alcohols Type A
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ORGANISMS: Rat (Wistar)
- Source: not reported
- Weight at study initiation: mean weight 190g
- Group size: 10 F
- Controls: no
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- ADMINISTRATION: Gavage
- Doses: 5 and 10g/kg
- Doses per time period: Single
- Volume administered or concentration: 20 ml/kg constant dose as a solution in olive oil
- Post dose observation period: 14 days
EXAMINATIONS: The animals were observed for mortality and clinical signs. - Doses:
- 5000 and 10000 mg/kg
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- ADMINISTRATION: Gavage
- Doses: 5 and 10g/kg
- Doses per time period: Single
- Volume administered or concentration: 20 ml/kg constant dose as a solution in olive oil
- Post dose observation period: 14 days - Statistics:
- No statistical analysis of the results was carried out in this study.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths during the study.
- Clinical signs:
- other: No signs of intoxiciation
- Other findings:
- NECROPSY FINDINGS: Necropsy not carried out.
POTENTIAL TARGET ORGANS: No indication given.
SEX-SPECIFIC DIFFERENCES: Only females teste
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The rat oral LD50 for this C12-14 alcohol Lorol Spezial type 70 was >10000 mg/kg. There were no signs of intoxication.
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