Registration Dossier
Registration Dossier
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EC number: 279-420-3 | CAS number: 80206-82-2
Toxicity to other above-ground organisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to other above-ground organisms
- Type of information:
- other: published data
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 71-3 (Wild Mammal Acute Toxicity Test)
- GLP compliance:
- not specified
- Analytical monitoring:
- no
- Vehicle:
- yes
- Test organisms (species):
- rat
- Details on test organisms:
- TEST ORGANISMS:
Rattus norvegicus (Norway Rat). The sexually mature organism(s) (age: 68-85 d and organism characteristics of: 365.1 G,PREGNANT, OUTBRED STRAIN/) - Study type:
- laboratory study
- Limit test:
- no
- Total exposure duration:
- 20 d
- Test temperature:
- 10-20 0C
Temperature was continuously recorded - Photoperiod and lighting:
- They were held at a photoperiod of 14:10 light:dark.
- Nominal and measured concentrations:
- DOSES/130/650/975/1300 mg/kg/d
- Reference substance (positive control):
- not specified
- Duration:
- 10 d
- Dose descriptor:
- other: NOEL
- Effect conc.:
- 130 mg/kg bw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: NR-ZERO was reported (NOEL) Zero Mortality: 0% mortality or 100% survival of organisms. (No statistically derived endpoint reported)
- Duration:
- 10 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 2 600 mg/kg diet
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- TheNOELs can be converted to NOECs with the following two formulae: NOECrat=NOELrat.CONVrat Conversion factors from NOEL to NOEC for mammalian species Rattus norvegicus (> 6 weeks) is 20 (bw/dfi)
- Basis for effect:
- mortality
- Remarks on result:
- other: NOECrat=130 x 20=2600 mg/kg/diet Conversion factors from NOEL to NOEC for mammalian species Rattus norvegus >6 weeks is 20 (bw/dfi) bw = body weight (g); dfi: daily food intake (g/day)
- Duration:
- 20 d
- Dose descriptor:
- other: NOEL
- Effect conc.:
- 1 300 mg/kg bw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- behaviour
- Remarks:
- Measurement: Abnormal,Weight;
- Duration:
- 20 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 26 000 mg/kg diet
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- TheNOELs can be converted to NOECs with the following two formulae: NOECrat=NOELrat.CONVrat Conversion factors from NOEL to NOEC for mammalian species Rattus norvegicus (> 6 weeks) is 20 (bw/dfi)
- Basis for effect:
- behaviour
- Remarks:
- Measurement: Abnormal,Weight;
- Remarks on result:
- other: NOECrat=1300 x 20=26000 mg/kg/diet Conversion factors from NOEL to NOEC for mammalian species Rattus norvegus >6 weeks is 20 (bw/dfi) bw = body weight (g); dfi: daily food intake (g/day)
- Details on results:
The NOEL for the Rattus norvegicus was 130 mg/kg bw for mortality
The NOEL for the Rattus norvegicus was 1300 mg/kg bw for Abnormal and Weight effects
For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC.
TheNOELs can be converted to NOECs with the following two formulae:
NOECrat=NOELrat.CONVrat
Conversion factors from NOEL to NOEC for mammalian species Rattus norvegicus (> 6 weeks) is 20 (bw/dfi)
bw = body weight (g); dfi: daily food intake (g/day)
NOECrat=130 x 20=2600 mg/kg/diet- Validity criteria fulfilled:
- yes
- Conclusions:
- The NOEL for the Rattus norvegicus was 130 mg/kg bw for mortality
The NOEL for the Rattus norvegicus was 1300 mg/kg bw for Abnormal and Weight effects
For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC.
TheNOELs can be converted to NOECs with the following two formulae:
NOECrat=NOELrat.CONVrat
Conversion factors from NOEL to NOEC for mammalian species Rattus norvegicus (> 6 weeks) is 20 (bw/dfi)
bw = body weight (g); dfi: daily food intake (g/day)
NOECrat=130 x 20=2600 mg/kg/diet - Executive summary:
The NOEL for the Rattus norvegicus was 130 mg/kg bw for mortality The NOEL for the Rattus norvegicus was 1300 mg/kg bw for Abnormal and Weight effects For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC. TheNOELs can be converted to NOECs with the following two formulae: NOECrat=NOELrat.CONVrat Conversion factors from NOEL to NOEC for mammalian species Rattus norvegicus (> 6 weeks) is 20 (bw/dfi) bw = body weight (g); dfi: daily food intake (g/day) NOECrat=130 x 20=2600 mg/kg/diet
- Endpoint:
- toxicity to other above-ground organisms
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Referenceopen allclose all
A study of NC-NC Not Coded duration using no substrate
media was conducted in a Lab site location with Not Coded
obtained Rattus norvegicus (Norway Rat). The sexually
mature organism(s) (age: 68-85 d and organism
characteristics of: 365.1 G,PREGNANT, OUTBRED STRAIN/) were
exposed for a duration of 10 day(s) to a(n) 10 Daily
for X days application of 1-Octanol (CAS # 111875) in NR
carrier or a(n) NR positive control through a(n) gavage
exposure route. The reported chemical concentrations are the result of unmeasured
analysis of chemical solutions and are based on the NR ion.
(Reference 84162, Hellwig, J., and R. Jackh, 1997, Test Number 406282).
Description of key information
The NOEL for the Rattus norvegicus was 130 mg/kg bw for mortality
The NOEL for the Rattus norvegicus was 1300 mg/kg bw for Abnormal and Weight effects
For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC.
TheNOELs can be converted to NOECs with the following two formulae:
NOECrat=NOELrat.CONVrat
Conversion factors from NOEL to NOEC for mammalian species Rattus norvegicus (> 6 weeks) is 20 (bw/dfi)
bw = body weight (g); dfi: daily food intake (g/day)
NOECrat=130 x 20=2600 mg/kg/diet
Key value for chemical safety assessment
- Short-term EC50 or LC50 for mammals:
- 13 000 mg/kg food
- Long-term EC10, LC10 or NOEC for mammals:
- 2 600 mg/kg food
Additional information
The NOEL for the Rattus norvegicus was 130 mg/kg bw for mortality
The NOEL for the Rattus norvegicus was 1300 mg/kg bw for Abnormal and Weight effects
For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC.
TheNOELs can be converted to NOECs with the following two formulae:
NOECrat=NOELrat.CONVrat
Conversion factors from NOEL to NOEC for mammalian species Rattus norvegicus (> 6 weeks) is 20 (bw/dfi) bw = body weight (g); dfi: daily food intake (g/day)
NOECrat=130 x 20=2600 mg/kg/diet
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