Alcohols, C12-14

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1980

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Draize Test

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Alcohols, C12-14

EC Number:

279-420-3

EC Name:

Alcohols, C12-14

Cas Number:

80206-82-2

Molecular formula:

C13H28O

IUPAC Name:

Alcohols, C12-14

Details on test material:

- Name of test material (as cited in study report)Tradename Lorol Spezial type 70 C12-14 alcohols Type AType A. 100% Linear; >90% C12/14 (C12>14), <10% C16 [range C6-C18];

Test animals / tissue source

Species:

rabbit

Strain:

New Zealand White

Details on test animals or tissues and environmental conditions:

TTEST ANIMALS:
-Rabbit
- Strain: New Zealand White
- Sex: Male
- Source: Not reported
- Age: Not reported
- Weight at study initiation: Not reported
- Number of animals: 6
- Controls: The untreated eye served as a control.

Test system

Vehicle:

unchanged (no vehicle)

Controls:

yes

Amount / concentration applied:

0.1 mL

Duration of treatment / exposure:

24 hours

Observation period (in vivo):

24 hours

Number of animals or in vitro replicates:

6

Details on study design:

ADMINISTRATION/EXPOSURE
- Preparation of test substance: Undiluted
- Amount of substance instilled: 0.1 ml
- Vehicle: none
- Postexposure period: 24 hours
- Controls: The untreated eye served as a control.

EXAMINATIONS
- Ophthalmoscopic examination: Not reported.
- Scoring system: Draize
- Observation period: 24 hours
- Tool used to assess score: Not reported.

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: 24 hrs

Score:

0

Reversibility:

fully reversible

Remarks:

Fully reversible by 24 hours after instillation.

Remarks on result:

other: not rinsed. Draize scoring up to 24 hours post instillation. There was no involvement of the cornea or iris. Minimal conjunctival redness was noted (score <1) at 2 and 6 hours after instillation. All scores at 24 hours were 0.

Irritant / corrosive response data:

Draize scoring up to 24 hours post instillation. There was no involvement of the cornea or iris. Minimal conjunctival redness was noted (score <1) at 2 and 6 hours after instillation. All scores at 24 hours were 0.

Applicant's summary and conclusion

Interpretation of results:

other: not irritating

Remarks:

Criteria used for interpretation of results: EU

Conclusions:

This C12-14 alcohol is not irritating to the eye when applied undiluted.
Result: not irritating .

Executive summary:

This C12-14 alcohol is not irritating to the eye when applied undiluted.

Result: not irritating .