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EC number: 600-198-4 | CAS number: 101377-47-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test substance was administered by gavage to six male rats. Rats were dosed at 300 mg/kg/day for 10 days (weekends excluded) over a 2-week period. Six rats were simultaneously dosed with corn oil as a control. All rats were weighed and observed daily during the dosing period. After the tenth dose, three control and three test rats were sacrificed. The remaining rats in each group were weighed and observed through a 14-day recovery period and then sacrificed. All sacrificed rats were examined grossly and selected tissues evaluated histologically.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- bis(4-fluorophenyl)methyl(4H-1,2,4-triazol-4yl-methyl)silane
- EC Number:
- 600-198-4
- Cas Number:
- 101377-47-3
- Molecular formula:
- C16H15N3F2Si
- IUPAC Name:
- bis(4-fluorophenyl)methyl(4H-1,2,4-triazol-4yl-methyl)silane
- Details on test material:
- - Purity: approximately 95%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 2-weeks
- Frequency of treatment:
- Daily for 10 days (weekends excluded) over a 2-week period
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Males: 300 mg/kg
Basis:
actual ingested
- No. of animals per sex per dose:
- Control and the test group consisted of 6 male rats each. Three control and three test rats were used in a 14-day recovery group.
- Control animals:
- yes, concurrent vehicle
Results and discussion
Effect levels
- Dose descriptor:
- conc. level:
- Effect level:
- 300 mg/kg bw/day (actual dose received)
- Sex:
- male
- Basis for effect level:
- other: clinical signs (stained and wet perineal area, red oral and nasal discharges, alopecia, aggressive behavior, and limpness); decreased body weight; increased liver/body weight and testes/body weight ratios; histopathology (liver and urinary bladder).
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
CLINICAL SIGNS AND MORTALITY
All rats survived. Clinical signs observed in test rats during the dosing period included stained and wet perineal area, red oral and nasal discharges, alopecia, aggressive behavior, and limpness. Alopecia was observed during recovery.
BODY WEIGHT AND WEIGHT GAIN
Body weights of test rats were significantly lower than those of control rats from Test Day 2 though Test Day 12. Slight to moderate weight loss was observed in test rats during the dosing period. Slight weight loss was observed during recovery.
ORGAN WEIGHTS Following 10 doses, test rats had significantly increased liver/body weight and testis/body weight ratios over control rats. Fourteen days following dosing, there were no significant differences between test rats and controls.
HISTOPATHOLOGY: NON-NEOPLASTIC
Histologically, compound-related changes were found in the liver and urinary bladder. The change in the liver was a lipid-like cytoplasmic vacuolation in hepatocytes at zero days recovery. The change in the bladder was a moderate diffuse hyperplasia of the urothelium at zero days recovery, with a partial recovery after 14 days.
Applicant's summary and conclusion
- Conclusions:
- All rats survived. Clinical signs and weight loss were observed during the dosing period. Histologic examination revealed compound related effects in the liver and urinary bladder. There was complete recovery in the liver and partial recovery in the urinary bladder in rats given a 14-day recovery period. Increased liver/body weight and testes/body weight ratios were observed in test rats sacrificed after the 10th dose. Fourteen days after dosing, there were no significant differences between test rats and controls.
- Executive summary:
- The test substance was administered by gavage to six male rats. Rats were dosed at 300 mg/kg/day for 10 days (weekends excluded) over a 2-week period. Six rats were simultaneously dosed with corn oil as a control. All rats were weighed and observed daily during the dosing period. After the tenth dose, three control and three test rats were sacrificed. The remaining rats in each group were weighed and observed through a 14-day recovery period and then sacrificed. All sacrificed rats were examined grossly and selected tissues evaluated histologically. All rats survived. Clinical signs observed in test rats during the dosing period included stained and wet perineal area, red oral and nasal discharges, alopecia, aggressive behavior, and limpness. Alopecia was observed during recovery. Body weights of test rats were significantly lower than those of control rats from Test Day 2 though Test Day 12. Slight to moderate weight loss was observed in test rats during the dosing period. Slight weight loss was observed during recovery. Following 10 doses, test rats had significantly increased liver/body weight and testis/body weight ratios over control rats. Fourteen days following dosing, there were no significant differences between test rats and controls. Gross pathologic examination revealed no compound-related effects. Histologic examination revealed compound-related effects in the liver and urinary bladder. There was complete recovery in the liver and partial recovery in the urinary bladder in rats given a 14-day recovery period.
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