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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1983
Report date:
1983

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The test substance, suspended in corn oil, was administered by gavage to male rats as a single oral dose at dose levels of 450, 670, 1000, 1500, and 2250 mg/kg. After dosing, the rats were checked periodically for toxic signs. Surviving rats were weighed and observed for 14 days after dosing.
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Purity: approximately 95%

Test animals

Species:
rat
Strain:
other: Crl:CD
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Doses:
450, 670, 1000, 1500, 2250 mg/kg
No. of animals per sex per dose:
one
Control animals:
no

Results and discussion

Effect levels
Dose descriptor:
other: ALD
Effect level:
1 500 mg/kg bw

Any other information on results incl. tables

Rats dosed at 1500 and 2250 mg/kg died.

All rats that died exhibited stained perinea and decreased muscle tone. The rat receiving 2250 mg/kg had a discharge from the eyes and mouth one day after dosing. The rat receiving 1000 mg/kg experienced some hair loss on its abdomen and perineal area.

All rats that died exhibited severe weight loss. All surviving rats exhibited moderate weight loss 1-2 days after dosing followed by normal weight gain.

Applicant's summary and conclusion

Interpretation of results:
sligthly toxic
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
ALD = 1500 mg/kg
Executive summary:

The test substance, suspended in corn oil, was administered by gavage to male rats as a single oral dose at dose levels of 450, 670, 1000, 1500, and 2250 mg/kg. After dosing, the rats were checked periodically for toxic signs. Surviving rats were weighed and observed for 14 days after dosing. Rats dosed at 1500 and 2250 mg/kg died. All rats that died exhibited stained perinea and decreased muscle tone. The rat receiving 2250 mg/kg had a discharge from the eyes and mouth one day after dosing. The rat receiving 1000 mg/kg experienced some hair loss on its abdomen and perineal area. All rats that died exhibited severe weight loss. All surviving rats exhibited moderate weight loss 1-2 days after dosing followed by normal weight gain. The ALD for the test substance in rats is 1500 mg/kg.