4H-1,2,4-Triazole, 4-[[bis(4-fluorophenyl)methylsilyl]methyl]-

Short-term toxicity to fish

Administrative data

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: No analytical monitoring

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1988

Report date:

1988

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

Deviations:

no

Remarks:

Conducted according to guideline in effect at time of study conduct

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

bis(4-fluorophenyl)methyl(4H-1,2,4-triazol-4yl-methyl)silane

EC Number:

600-198-4

Cas Number:

101377-47-3

Molecular formula:

C16H15N3F2Si

IUPAC Name:

bis(4-fluorophenyl)methyl(4H-1,2,4-triazol-4yl-methyl)silane

Details on test material:

- Purity: R7623 Technical, solid

Sampling and analysis

Analytical monitoring:

no

Test solutions

Vehicle:

yes

Test organisms

Test organisms (species):

Poecilia reticulata

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

96 h

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

5.7 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: 4.7 - 9.8 mg/L

Effect concentrations 2

Duration:

96 h

Dose descriptor:

NOEC

Effect conc.:

1 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: at 1.8 mg/L fish showed decreased swimming ability; at 3.2 and 5.6 mg/L: increased pigmentation, decreased swimming ability and mortality in 2 out of 10 fish

Any other information on results incl. tables

Sublethal observations / clinical signs:

After 24 hours of exposure 100% mortality was observed at 10 mg/L.

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

96-h LC50 = 5.7 mg/L

Executive summary:

An acute, static 96-hour test was conducted at nominal concentrations of 0, 0.56, 1.0, 1.8, 3.2, 5.6 and 10.0 mg/L on Poecilia reticulata. Exposure after 24 hours resulted in 100% mortality at 10 mg/L. Based on nominal concentration , the EC50 was 5.7 mg/L and the NOEC was 1 mg/L.