Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No analytical monitoring

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1988
Report date:
1988

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Deviations:
no
Remarks:
Conducted according to guideline in effect at time of study conduct
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Purity: R7623 Technical, solid

Sampling and analysis

Analytical monitoring:
no

Test solutions

Vehicle:
yes

Test organisms

Test organisms (species):
Poecilia reticulata

Study design

Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h

Results and discussion

Effect concentrationsopen allclose all
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
5.7 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Remarks on result:
other: 4.7 - 9.8 mg/L
Duration:
96 h
Dose descriptor:
NOEC
Effect conc.:
1 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: at 1.8 mg/L fish showed decreased swimming ability; at 3.2 and 5.6 mg/L: increased pigmentation, decreased swimming ability and mortality in 2 out of 10 fish

Any other information on results incl. tables

Sublethal observations / clinical signs:

After 24 hours of exposure 100% mortality was observed at 10 mg/L.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
96-h LC50 = 5.7 mg/L
Executive summary:

An acute, static 96-hour test was conducted at nominal concentrations of 0, 0.56, 1.0, 1.8, 3.2, 5.6 and 10.0 mg/L on Poecilia reticulata. Exposure after 24 hours resulted in 100% mortality at 10 mg/L. Based on nominal concentration , the EC50 was 5.7 mg/L and the NOEC was 1 mg/L.