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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Dissociation constant

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Administrative data

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dissociation constant
Type of information:
other: Handbook value
Adequacy of study:
key study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Reviewed handbook value. This study was selected as the key study because the information provided for the hazard endpoint is sufficient for the purpose of classification and labelling and/or risk assessment.
no guideline available
Principles of method if other than guideline:
No data available on method. The value used is a published Handbook value.
Dissociating properties:
<= 1.83
0 °C
The dissociation constant of betaine is 1.83 at 0°C.
Executive summary:

The dissociation constant of betaine is 1.83 at 0°C.

Description of key information

The value was obtained from a generally accepted handbook of Chemistry and Physics 89th Edition (2008).

Key value for chemical safety assessment

Additional information

pKa of betaine is 1.83 at 0°C.