Registration Dossier
Registration Dossier
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EC number: 203-490-6 | CAS number: 107-43-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Betaine in human nutrition
- Author:
- Stuart AS Graig
- Year:
- 2 004
- Bibliographic source:
- American Journal of Clinical Nutrition 80:539-49
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- Review article of a well-established metabolism route for betaine, oxidation product of choline within the human body.
- GLP compliance:
- no
Test material
- Reference substance name:
- Betaine
- EC Number:
- 203-490-6
- EC Name:
- Betaine
- Cas Number:
- 107-43-7
- Molecular formula:
- C5H11NO2
- IUPAC Name:
- (trimethylammonio)acetate
Constituent 1
Test animals
- Species:
- human
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- not specified
Results and discussion
Main ADME results
- Type:
- metabolism
- Results:
- Completely metabolized by liver and kidney cells by methylation to dimethylglycine and ultimately to serine.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Dimethylglycine
Applicant's summary and conclusion
- Conclusions:
- Betaine is completely metabolized by liver and kidney cells, a very small amount is passed in urine.
- Executive summary:
Completely metabolized by liver and kidney cells by methylation to dimethylglycine and ultimately to serine; a very small amount is passed in urine.
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