Registration Dossier
Registration Dossier
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EC number: 203-490-6 | CAS number: 107-43-7
Toxicity to reproduction
Administrative data
- Endpoint:
- screening for reproductive / developmental toxicity
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: EC JRC validated QMRF and completely fulfilled QPRF, betaine falls within the applicabitility domain of the model.
- Justification for type of information:
- QSAR prediction
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
- Reference Type:
- other: QMRF
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- QSAR-modelling following QMRF reported as QPRF
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Betaine
- EC Number:
- 203-490-6
- EC Name:
- Betaine
- Cas Number:
- 107-43-7
- Molecular formula:
- C5H11NO2
- IUPAC Name:
- (trimethylammonio)acetate
Constituent 1
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Dose descriptor:
- other: Estrogen receptor binding
- Basis for effect level:
- other: The predicted value of log(ER-RBA) = -13.38 is far on the side of non-binding compounds on the scale of binders, weak binders and non-binders. Therefore, it can be concluded that the test substance does not bind Estrogen receptor B.
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The predicted value of log(ER-RBA) = -13.38 is far on the side of non-binding compounds on the scale of binders, weak binders and non-binders. Therefore it can be concluded that the test substance does not bind Estrogen receptor B.
- Executive summary:
The predicted value of log(ER-RBA) = -13.38 is far on the side of non-binding compounds on the scale of binders, weak binders and non-binders. Therefore it can be concluded that the test substance does not bind Estrogen receptor B.
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