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Toxicological information

Toxicity to reproduction

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Administrative data

Endpoint:
screening for reproductive / developmental toxicity
Remarks:
based on test type (migrated information)
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: EC JRC validated QMRF and completely fulfilled QPRF, betaine falls within the applicabitility domain of the model.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
2010
Report Date:
2010
Reference Type:
other: QMRF
Title:
Unnamed
Year:
2010
Report Date:
2010

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
QSAR-modelling following QMRF reported as QPRF
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Results: P0 (first parental animals)

Effect levels (P0)

Dose descriptor:
other: Estrogen receptor binding
Basis for effect level:
other: The predicted value of log(ER-RBA) = -13.38 is far on the side of non-binding compounds on the scale of binders, weak binders and non-binders. Therefore it can be concluded that the test substance does not bind Estrogen receptor B.
Remarks on result:
not measured/tested
Remarks:
Effect level not specified Generation not specified (migrated information)

Overall reproductive toxicity

Reproductive effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
The predicted value of log(ER-RBA) = -13.38 is far on the side of non-binding compounds on the scale of binders, weak binders and non-binders. Therefore it can be concluded that the test substance does not bind Estrogen receptor B.
Executive summary:

The predicted value of log(ER-RBA) = -13.38 is far on the side of non-binding compounds on the scale of binders, weak binders and non-binders. Therefore it can be concluded that the test substance does not bind Estrogen receptor B.