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EC number: 403-730-1 | CAS number: 2687-96-9
Based on available date, the most relevant reproducible effect, liver related changes in dogs, was identified as the basis for establishing the long-term DNELs. The NOEL for repeated exposure of rats in the 28 -day study was used for estimation of the acute DNELs. These data are more conservative than those identified in association with local and/or acute effects. The route-to-route extrapolation of DNELs is performed according to the ECHA Guidance Document R.8, Characterization of Dose [Concentration]-Response for Human Health dated November 2012.
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