Registration Dossier

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

A toxicity to aquatic algae study (Lane, 1987) is available of limited balidity as it does not follow current gu0idelines and is non-GLP. Effect concentrations were based on cells counted at the end of the test instead of calculating percentage of reduction of growth rates over a time interval. For the prupose of this dossier, calculations were performed with the individual data present in the report to generate effect concentrations on growth rate.

Key value for chemical safety assessment

EC50 for freshwater algae:
0.086 mg/L
EC10 or NOEC for freshwater algae:
0.046 mg/L

Additional information

Based on the detailed data including absorption measurements and microscopic cell counting, it was possible to calculate the growth rates for the 24 -96 h time interval. The table below shows the average data per test concentration and the percentages of growth rate reduction for the 24 -96 h interval. The key values are based on these additional calculations.

Average cell numbers
Concentration (mg/L) 24 h 48 h 72 h 96 h growth rate 24-96h Percentage reduction of growth rate
0 33852 165533 520621 1325019 0.037959
0.026 29559 163265 534888 1042328 0.040217 -6.0%
0.033 42328 141985 563265 1078420 0.035949 5.3%
0.046 24074 137037 523810 1248488 0.042778 -12.7%
0.061 21202 62925 129913 234694 0.025177 33.7%
0.098 21164 43504 57540 73885 0.013892 63.4%
0.153 22172 34801 57143 82577 0.013149 65.4%