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EC number: 403-730-1 | CAS number: 2687-96-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 21 May to 30 July 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study run to a method comparable with current guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: The methods described by Hagan served as a guide.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Type:
- Constituent
- Details on test material:
- Batch No.: not specified
Purity: not specified
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: a suitably licensed dealer
- Age at study initiation: approximately 6 to 9 weeks
- Weight at study initiation: 200 to 300g
- Fasting period before study: approximately 18 hours
- Housing: housed in galvanized cages with indirect bedding
- Diet (e.g. ad libitum): consisted of a growth and maintenance ration from a commercial producer, ad libitum.
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): a 12 hour light/dark cycle
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- test dose levels: 0.63, 1.00, 1.58, 2.52 and 5.00 g/kg bodyweight
- No. of animals per sex per dose:
- 5 males and 5 females per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations were made at least once daily thereafter for a total of 14 days. Animals were weighed on the first day of dosing and at the end of the 14 day.
- Necropsy of survivors performed: yes
- Other examinations performed: pharmacology activity, drug toxicity.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 050 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 240 - <= 3 380
- Mortality:
- The mortality of different dose leval as follows:
For dose level of 0.63g/kg, the mortality is 10%
For dose level of 1 g/kg, the mortality is 30%.
For dose level of 1.58g/kg , the mortality is 30%.
For dose level of 2.52 g/kg, the mortality is 10%
For dose level of 5.00g/kg, the mortality is 90%. - Clinical signs:
- No information provided.
- Body weight:
- No change observed.
- Gross pathology:
- For dose level of 0.63g/kg, one animal have gastric mucosa moderately reddened.
For dose level of 1 g/kg, one animal have abscess on mesentery in lower abdominal cavity, one animal have intestinal mucosa moderately reddened, lesions on superior, middle, and inferior lobes of right lung, one animal have abscess on left lung, and one animal have gastrointestinal mucosa slightly reddened.
For dose level of 1.58 g/kg, one animal have intestinal mucosa moderately reddened, one animal have gastric mucosa moderately reddened. one animal have dorsal surfaces of median, left, and caudate lobes of liver blanched, gastrointestinal mucosa severely reddened.
For dose level of 5.00 g/kg , six animals have all lobes of liver mottled and blanched, among which four animals also have the ventral aspect of left kindey blanched, one animal have forestomach moderatley reddened, one animal have forestomach severely reddened. - Other findings:
- No information provided.
Any other information on results incl. tables
Dose Level (g/kg) |
Sex |
No. Dead/No. Dosed (M:F) |
Mortality (%) |
0.63 |
5M:5F |
0/5:1/5 |
10 |
1.00 |
5M:5F |
0/5:3/5 |
30 |
1.58 |
5M:5F |
2/5:1/5 |
30 |
2.52 |
5M:5F |
0/5:1/5 |
10 |
5.00 |
5M:5F |
4/5:5/5 |
90 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral study in rats showed that the LD50 was 2.05 g/kg bodyweight.
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