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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

repeated dose toxicity: inhalation
other: assessment of published data
Type of information:
other: assessment of available data
Adequacy of study:
key study
Study period:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Reliability score 2 on the basis of the weight of evidence found during review of public documents relating to toxicity of sodium carbonate

Data source

Reference Type:
study report
Report date:

Materials and methods

Test guideline
no guideline followed
Principles of method if other than guideline:
Compilation and assessment of available published data for repeat dose toxicity
GLP compliance:

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium carbonate
EC Number:
EC Name:
Sodium carbonate
Cas Number:
Molecular formula:
disodium carbonate

Test animals

other: humans

Results and discussion

Effect levels

Dose descriptor:
Effect level:
> 10 mg/m³ air
Based on:
other: human experience
Basis for effect level:
other: No actual effect level value has been derived for human inhalation. Since there is no evidence of dust toxicity in humans, a value which is equivalent to nuisance dust has been assigned.
Remarks on result:
not determinable
no NOAEL identified

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Executive summary:

Sodium carbonate is produced on all continents of the world and the global number of production sites is estimated to be 50-70. The total world demand of sodium carbonate in 1999 was 33.4 million metric tonnes.

Sodium carbonate is used for the production of glass, soaps and detergents and other chemicals and it also used by the ‘metals and mining’ industry and the ‘pulp and paper’ industry. Sodium carbonate is not only used by industry but is also used by consumers. It may be used directly in solutions of sodium carbonate for soaking of clothes, dishwashing, floor washing and for degreasing operations but it is also present in a large number of consumer products like cosmetics, soaps, scouring powders, soaking and washing powders. Sodium carbonate is also a food additive.

Humans have been regularly exposed to sodium carbonate in various guises over a considerable length of time. There has been no significant reports of ill health caused by inhalation of sodium carbonate either in powder or aerosol form