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Key value for chemical safety assessment

Additional information

The available in vitro tests (SOS chromotest, Ames test and Chromosome aberration test with sodium carbonate) were negative.

When the pH will be kept below 8 to have a good functioning biological test system, mainly bicarbonate will be available. Furthermore, sodium bicarbonate is naturally present in cells and both the structure of sodium bicarbonate and sodium carbonate do not indicate a genotoxic potential. Therefore, there is no reason to evaluate the potential genotoxicity of sodium carbonate further and no genotoxic effects are expected.

[partly taken from OECD SIDS on sodium carbonate (2002), pg. 16]

Short description of key information:
Sodium carbonate is not considered to be genotoxic based on available information on the analogous substance sodium bicarbonate (Ames Test with negative result; Ishidate et al, 1984).

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Based on the available information, no classification for genetic toxicity is required in accordance with EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No.1272/2008.