Sodium carbonate

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1978

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

In the OECD SIDS on sodium carbonate (2002) a similar reliability was assigned.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: EPA 16 CFR 1500.40

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Sodium carbonate

EC Number:

207-838-8

EC Name:

Sodium carbonate

Cas Number:

497-19-8

Molecular formula:

CH2O3.2Na

IUPAC Name:

disodium carbonate

Details on test material:

SOURCE: Not reported.
PURITY: Not reported.
IMPURITY/ADDITIVE/ETC.: Not reported.
ANY OTHER INFORMATION: The test substance was sodium
carbonate monohydrate.

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ORGANISMS: New Zealand White Albino Rabbits.
- Source: Marland Breeding Farms, Inc., Hewitt, NJ.
- Age: Not reported.
- Weight at study initiation: 2.50-3.40 kg.
- Controls: Not reported. 3 animals had abraded skin, and 3 animals had non-abraded skin.

Administration / exposure

Vehicle:

water

Details on dermal exposure:

ADMINISTRATION: The hair of each rabbit was clipped from the trunk so as to expose at least 30% of the body surface area. The skin of half the animals was abraded longitudinally every two or 3 cm over the area of exposure. The operations were deep enough so as to penetrate the stratum corneum, but not so deep as to disturb the derma or produced bleeding.
- Area covered: The test material was administered to the clipped area.
- Occlusion: The test material was held in contact with the skin by a sleeve made of impervious plastic sheeting designed to contain the dose without leakage or undue pressure.
- Concentration in vehicle: the test material was administered as a 1000 mg/ml aqueous slurry.
- Total volume applied: Not reported.
- Doses: 2000 mg/kg.
- Removal of test substance: After 24 hrs of exposure, the exposed area was wiped free of excess test material.

Doses:

2000 mg/kg bw as a 1000 mg/ml aqueous slurry.

No. of animals per sex per dose:

6

Statistics:

STATISTICAL METHODS: Not reported.

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Mortality:

No deaths occurred during the experiment.

Clinical signs:

other: 3/6 animals gained weight during the 14 days the experiment lasted. 3/6 animals lost weight or did not gain weight. Well-defined to severe erythema and slight to severe oedema were observed in all six animals at the 24-hour dermal observations. The sever

Gross pathology:

NECROPSY FINDINGS: Not reported.

Other findings:

POTENTIAL TARGET ORGANS: Skin.
SEX-SPECIFIC DIFFERENCES: Not reported.