Registration Dossier

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.2 mg/m³
Most sensitive endpoint:
neurotoxicity
Route of original study:
By inhalation
DNEL related information
DNEL derivation method:
other: use of OEL as DNEL
Acute/short term exposure
Hazard assessment conclusion:
hazard unknown (no further information necessary)
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

Workers - Hazard for the eyes

Local effects

Hazard assessment conclusion:
low hazard (no threshold derived)

Additional information - workers

See discussion below.

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
hazard unknown (no further information necessary)
Acute/short term exposure
Hazard assessment conclusion:
hazard unknown (no further information necessary)
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard for the eyes

Local effects

Hazard assessment conclusion:
low hazard (no threshold derived)

Additional information - General Population

The inhalation toxicity of manganese bis(dihydrogen phosphate) is influenced by the Mn2+ cation and as such the material is considered to be classified via the inhalation route as STOT RE2 (target organ brain) in accordance with Regulation (EC) No. 1272/2008 (EU CLP) and on the basis of neurological symptoms (neurotoxicity) observed after inhalation of manganese. Neurotoxicity is considered to be the leading health effect and as such an IOELV has been proposed and adopted by the European Commission (1). This relates primarily to cumulative exposures however the authors state that as the proposed values are not based on one single study but on a database of available data the values proposed are acceptable for use in the risk mitigation of both cumulative and peak exposures.

 

The values are as follows:

- Inhalable IOELV: 0.2 mg/m3

- respirable IOELV: 0.05 mg/m3

It is recommended that both values should be observed conjointly.

(1) ‘Recommendation from the Scientific Committee on Occupational Exposure Limits for Manganese and Inorganic Manganese Compounds’. SCOEL/SUM/127 – Adopted by the European Commission, June 2011