Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 283-406-2 | CAS number: 84625-32-1 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Eucalyptus globulus, Myrtaceae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Long-term toxicity to fish
Administrative data
- Endpoint:
- long-term toxicity to fish
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- Eucalyptus globulus oil is a Natural Complex Substance (NCS) and hazard properties are derived from the hazard properties of the main constituents (greater than 10% in the NCS: 1,8-cineol, d/l-limonene and α-pinene). According to column 2 of Annex VII, section 9.1.1 of the REACH Regulation, a long-term study shall be considered if the substance is poorly water soluble. In the ECHA Guidance document chapter R7b, the limit value of 1 mg/L is given to consider poorly water soluble substances (TGD, 2003). The water solubility of the known constituent are 2.65 mg/L ((d,l)-limonene), 1.82 mg/L (alpha-pinene) and 3500 mg/L (1,8-cineol). Therefore, all main constituent exhibit a low water solubility but do not meet the criterion for poorly water soluble substance. Moreover, for a substance with a low water solubility, long-term tests are performed when short-term toxicity tests do not reveal any toxicity (ECHA Guidance document chapter R.7b). Reliable short-term toxicity studies revealed toxicity for any main constituent tested individually or the Eucalyptus globulus oil tested itself. The information on the Mode of Action (MoA) of the main constituents is available. They have a narcotic MoA, which is considered to be the baseline toxicity MoA, the least toxic MoA. The aquatic toxicity data available on main constituent suggest a similar sensitivity between the three taxonomic groups towards the main constituent, which has a non-specific mode of action (non-polar narcosis). This is in accordance with ECHA Guidance document chapter R.10 where it is stated that interspecies variations may be low for substances with a known non-specific mode of action. As a consequence, deriving the PNECwater by using acute toxicity data and an assessment factor is considered conservative enough to cover among others the acute-to-chronic extrapolation. The chemical safety assessment has been conducted in accordance. Moreover, all constituent are readily biodegradable and exhibit a log Kow < 4.5 and estimated BCF below 2000 L/kg. Consequently, the constituent are definitively not P and not B. Therefore, a long-term testing to fish is not considered as necessary to refine the chemical safety assessment and the PBT assessment.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
