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Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
2002
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only short abstract available
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
publication
Title:
Gas Chromatography: An Investigative Tool in Multiple Allergies to Essential Oils.
Author:
Dharmagunawardena B, Takwale A, Sanders KJ, Cannan S, Rodger A and Ilchyshyn A
Year:
2002
Bibliographic source:
Contact Dermatitis. 47(5): 288-292

Materials and methods

Type of sensitisation studied:
skin
Study type:
case report
Principles of method if other than guideline:
Method: Single Patch test performed in patients
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: oil
Details on test material:
- Name of test material (as cited in study report): Eucalyptus oil

Method

Type of population:
other: clinical cases presented with suspected allergic contact dermatitis
Controls:
No
Route of administration:
dermal

Results and discussion

Results of examinations:
- Eucalyptus oil showed a positive reaction (palpable erythema) in one female on Day 4.
- It was found to be composed only of eucalyptol together with α- and β-pinene.

Any other information on results incl. tables

None

Applicant's summary and conclusion

Conclusions:
Eucalyptus oil showed a positive reaction (palpable erythema) in one female on Day 4. It was found to be composed only of eucalyptol together with α- and β-pinene.
Executive summary:

In a skin sensitisation study, two female patients (50 and 51 year old professional aromatherapists presented with suspected allergic contact dermatitis) were applied with occlusive patches containing eucalyptus oil diluted in white petrolatum, for 48 h. The reactions were observed at 30 min. after removal of patches and on Day 4. The composition of the oil was analysed using GC-MS chromatography.

Eucalyptus oil showed a positive reaction (palpable erythema) in one female on Day 4. It was found to be composed only of eucalyptol together with α- and β-pinene.