Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name:
  • IUPAC name: 1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane; 1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene; 2,6,6-trimethylbicyclo[3.1.1]hept-2-ene
  • Substance names and other identifiers
EC / List no.:
283-406-2
CAS no.:
84625-32-1
Index number:
Molecular formula:
C30H50O
SMILES:
CC(=C)C1CCC(C)=CC1.CC1=CCC2CC1C2(C)C.CC12CCC(CC1)C(C)(C)O2
InChI:
InChI=1/C10H18O.2C10H16/c1-9(2)8-4-6-10(3,11-9)7-5-8;1-7-4-5-8-6-9(7)10(8,2)3;1-8(2)10-6-4-9(3)5-7-10/h8H,4-7H2,1-3H3;4,8-9H,5-6H2,1-3H3;4,10H,1,5-7H2,2-3H3
Type of substance:
UVCB
Origin:
Organic
Registered compositions:
25
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the classification provided by companies to ECHA in REACH registrations this substance may be fatal if swallowed and enters airways, is toxic to aquatic life with long lasting effects, is a flammable liquid and vapour, causes skin irritation and may cause an allergic skin reaction.

Breakdown of all 2009 C&L notifications submitted to ECHA

Asp. Tox. 1 H304
Flam. Liq. 3 H226
Skin Sens. 1 H317
Aquatic Chronic 2 H411
Skin Irrit. 2 H315
Skin Sens. 1B H317
Not Classified
Eye Irrit. 2 H319
Aquatic Acute 1 H400
Aquatic Chronic 1 H410
Eye Dam. 1 H319
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • Ss
There is broad agreement in that a majority of data submitters agree this substance is Skin sensitising (100% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 46 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance has not been registered under the REACH Regulation, therefore as yet ECHA has not received any data about this substance from registration dossiers.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: washing & cleaning products, air care products, biocides (e.g. disinfectants, pest control products) and polishes and waxes.

Other release to the environment of this substance is likely to occur from: indoor use as processing aid and outdoor use as processing aid.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: washing & cleaning products and polishes and waxes.

ECHA has no public registered data on the types of manufacture using this substance.

This substance is used in the following activities or processes at workplace: roller or brushing applications, transfer of chemicals and non-industrial spraying.

Other release to the environment of this substance is likely to occur from: indoor use as processing aid and outdoor use as processing aid.

This substance is used in the following products: perfumes and fragrances and cosmetics and personal care products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, laboratory work, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: washing & cleaning products.

ECHA has no public registered data on the types of manufacture using this substance.

This substance is used in the following activities or processes at workplace: transfer of chemicals, industrial spraying and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites.

This substance is used in the following activities or processes at workplace: transfer of chemicals at dedicated facilities, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, laboratory work and closed processes with no likelihood of exposure.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: ground and bond container and receiving equipment; take actions to prevent static discharges; contaminated work clothing should not be allowed out of the workplace; keep away from heat, sparks, open flames and/or hot surfaces – No smoking; keep container tightly closed; use explosion-proof equipment (electrical/ventilating/lighting/etc.); avoid release to the environment; use non-sparking tools; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray.

Response statements

In case of incident: Wash contaminated clothing before reuse. If skin irritation or a rash occurs: get medical advice/attention. If swallowed: immediately call a poison center or doctor/physician. If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. Collect spillage. Do not induce vomiting. If on skin: wash with soap and water.

Storage statements

Store this substance in a dry place and in a closed container; in a well-ventilated place and Keeping it cool; locked up.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Augustus Oils Ltd, Augustus House Mill Lane GU34 2QG Alton Hampshire United Kingdom
  • Biolandes, Route de Belis 40420 Le Sen Landes France
  • BONTOUX S.A.S., Le clôt 26170 Saint Auban sur l'Ouvèze France
  • Chemical Inspection & Regulation Service Limited, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Chemservice GmbH - (J3D1), Herrnsheimer Hauptstrasse 1b 67550 Worms Germany
  • Claus Nitsche & Sohn GmbH, Billbrookdeich 122 D-22113 Hamburg Germany
  • De Monchy Europe Purchasing Ltd, Unit A, Blackhill Road Holton Heath Industrial Park, Holton Heath BH16 6LS Poole Dorset United Kingdom
  • doTERRA Europe Marketing, GmbH, Konrad-Zuse-Platz 4 81829 München Germany
  • Elixens UK Ltd, No 1 Essence House, Crabtree Road Thorpe Industrial Park TW20 8RN Egham Surrey United Kingdom
  • ERNESTO VENTOS, S.A., Carretera Reial 120B 08960 Sant Just Desvern Spain
  • ESENCIAS MARTINEZ LOZANO S.A., Ctra. Lorca, Km 7 - Paraje Venta de Cavila 30400 Caravaca de la Cruz Murcia Spain
  • F D Copeland & Sons Ltd, 5 Westfield Street SE18 5TL Woolwich LONDON United Kingdom
  • FIRMENICH GRASSE SAS OR 1, Parc Industriel Les Bois de Grasse 06130 Grasse France
  • Frey + Lau GmbH, Immenhacken 12 DE-24558 Henstedt-Ulzburg Germany
  • GARCIA PALOMO Y RODRIGUEZ, S.L., C/ LORENZO CRUZ, 31 21730 ALMONTE HUELVA Spain
  • Global Essence UK Limited, Parklands Business Centre, Stortford Road, Leaden Roding CM6 1GF Dunmow Essex United Kingdom
  • GOLGEMMA SA, route de FA 11260 ESPERAZA Languedoc Roussillon France
  • H. REYNAUD & FILS, La Cheminade 26570 MONTBRUN LES BAINS France
  • IFF Benicarlo, S.L., Avda. Felipe Klein 2 12580 Benicarlo Castellon Spain
  • INDUKERN, S.A., Alta Ribagorza, 6-8 08820 El Prat de Llobregat Barcelona Spain
  • International Flavors & Fragrances I.F.F. (Nederland) B.V., Liebergerweg 72-98 1221 JT Hilversum Netherlands
  • J C Buck Limited, Unit 8, The Stafford Estate Hillman Close, Ardleigh Green RM11 2SJ Hornchurch Essex United Kingdom
  • Johann Voegele KG, Bahnhofstrasse 143 74348 Lauffen Baden-Württemberg Germany
  • LLUCH ESSENCE, S.L., Lo Gaiter, 160 08820 EL PRAT DE LLOBREGAT CATALUÑA Spain
  • Pranarôm International sa, avenue des Artisans 37 7822 Ghislenghien Hainaut Belgium
  • Prinova Europe Limited, 10,Aldersgate Street EC1A 4HJ London United Kingdom
  • PRODASYNTH, PI DES BOIS DE GRASSE 4 AV. JOSEPH HONORE ISNARD 06130 GRASSE France
  • QUIMDIS SAS, 71, rue Anatole France 92532 Levallois-Perret France
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • Robertet, 37 Avenue Sidi Brahim 06130 Grasse France
  • Sensient Fragrances, S.A.U., Crta. Armilla Km 2,5 18100 Armilla Granada Spain
  • Shanghai Freemen Europe B.V., Lange Kleiweg 52H 2288GK Rijswijk Netherlands
  • SL de Plantas Aromáticas Industrializadas, C/ Antonio Gómez Millán, nº 29, Parque Tecnológico Citec 41120 Gelves Sevilla Spain
  • Socidestilda - Sociedade Portuguesa de Destilação de Óleos Essenciais, S.A., Rua Quinta da Galega de Cima, nº2, Quinta da Galega 2840-126 Seixal/Aldeia de Paio Pires Portugal
  • Symrise AG, Mühlenfeldstraße 1 37603 Holzminden Germany
  • Telmont Essentials (Ireland) PTE Limited, 84 Northumberland Road Dublin 4 Dublin Ireland
  • ULTRA INTERNATIONAL B.V., Malledijk 3H, 3208 LA Spijkenisse, (Loods 12-15) NETHERLANDS Netherlands
  • V. MANE FILS , 620 route de Grasse 06620 Le Bar sur Loup France
  • Vossen & Co NV/SA, Av. Van Volxem 264, C1 1190 Brussels Belgium
  • wspuk25, WSP House 70 Chancery Lane WC2A 1AF London United Kingdom

Substance names and other identifiers

Eucalyptus globulus, ext.
EC Inventory, REACH pre-registration
1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane; 1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene; 2,6,6-trimethylbicyclo[3.1.1]hept-2-ene
Registration dossier, Other
essential oil eucalyptus globulus - Eucalyptus globulus leaf oil
C&L Inventory
Essential oil of Eucalyptus globulus (Myrtaceae) obtained from leaves and branches by distillation
Registration dossier
Essential oil of Eucalyptus globulus (Myrtaceae) obtained from leaves and branches by distillation.
Registration dossier
eucaliptus essential oil
C&L Inventory
Eucalyptus
Registration dossier
Eucalyptus essential oil
C&L Inventory, Registration dossier
Eucalyptus Globules Leaf
C&L Inventory
Eucalyptus globulus
Registration dossier
EUCALYPTUS GLOBULUS ESSENTIAL OIL
C&L Inventory
Eucalyptus Globulus ext.
C&L Inventory
Eucalyptus globulus extract
C&L Inventory
EUCALYPTUS GLOBULUS HE
C&L Inventory
eucalyptus globulus leaf oil
C&L Inventory
Eucalyptus Globulus OE
C&L Inventory
Eucalyptus globulus oil
C&L Inventory, Registration dossier
Eucalyptus globulus, ess. oil
C&L Inventory
Eucalyptus globulus, ex
C&L Inventory
Eucalyptus globulus, ext
C&L Inventory
Eucalyptus globulus,ext
C&L Inventory
Eucalyptus globus extract
C&L Inventory
Eucalyptus Oil
C&L Inventory, Registration dossier
eucalyptus oil (cineole type)
C&L Inventory
EUCALYPTUS OIL EXTRAEUCALYPTUS OIL 80-85 % EUCALYPTUS OIL RECT.
Registration dossier
Eucalyptus Oil Globulus
Registration dossier
Eucalypyus Oil
C&L Inventory
Eucalytus Oil
C&L Inventory
HE Eucalyptus globulus
C&L Inventory
Reaction mass of p-mentha-1,4-diene and p-cymene and dipentene and (-)-pin-2(3)-ene
C&L Inventory
Reaction mass of pin-2(3)-ene and cineole and (S)-p-mentha-1,8-diene
C&L Inventory
EUCALYPTUS OIL 80-85 % SPANISH
Registration dossier
Eucalyptus Oil 80/85
Registration dossier
EUCALYPTUS OIL AUSTRALIA 80/85%
Registration dossier
EUCALYPTUS OIL CHIN. 80%
Registration dossier
Eucalyptus oil rectified
Registration dossier
EUCALYPTUS OIL SPAIN (ORGANIC BIO)
Registration dossier
Eukalyptus Öl
Registration dossier
8000-48-4
CAS number
C&L Inventory
84394-87-6
Deleted CAS number
Other
84625-32-1
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other
84837-11-6
Deleted CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 4 studies submitted
  • 4 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [4]
C Form
Liquid (100%) [2]
C Substance type
Natural substance (100%) [2]

Type of Study provided
Studies with data
Key study 2 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 6 studies submitted
  • 6 studies processed
R Melting / freezing point
-62.5 - 1.5 °C [6]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence 4
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Boiling point

Study results
  • 6 studies submitted
  • 5 studies processed
R Boiling point
153 - 184 °C @ 101 - 101.325 kPa [5]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence 4
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Density

Study results
  • 8 studies submitted
  • 6 studies processed
R Density
0.927 g/cm³ @ 20 °C [2]
R Relative density
0.859 - 0.92 @ 20 °C [4]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence 4
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Vapour pressure

Study results
  • 6 studies submitted
  • 6 studies processed
R Vapour pressure
2.07 - 6.33 hPa @ 25 °C [6]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 6
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Vapour pressure
3.51 hPa @ 25 °C

Partition coefficient

Study results
  • 6 studies submitted
  • 6 studies processed
R Log Pow
2.84 - 4.42 @ 25 °C and pH 0 - 14 [6]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 6
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Log Kow (Log Pow)
4.42

Water solubility

Study results
  • 6 studies submitted
  • 6 studies processed
R Water solubility (mass/vol.)
1.82 - 3 500 mg/L @ 21 - 25 °C and pH 0 - 14 [6]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2 4
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Water solubility
1.82 mg/L

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 8 studies submitted
  • 8 studies processed
R Flash point
33 - 48 °C @ 101 - 101.325 kPa [8]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence 6
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flash point at 101 325 Pa
45.5 °C

Auto flammability

Study results
  • 6 studies submitted
  • 6 studies processed
R Autoflammability / self-ignition
237 - 270 °C @ 99.057 - 101.325 kPa [6]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence 4
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Autoflammability / self-ignition at 101 325 Pa
270 °C

Flammability

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 3
Sci. unjustified 3
Exposure cons.
Other
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flammability
Flammable (100%)

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 8 studies submitted
  • 1 study processed
R dynamic viscosity (in mPa s)
1.63 - 2.46 [2]
R kinematic viscosity (in mm²/s)
1.79 [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence 6
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Dynamic viscosity at 20 °C
2.46 mPa.s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 18 studies submitted
  • 6 studies processed
C Interpretation of results
Readily biodegradable (100%) [6]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 18
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 6
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Bioaccumulation Factor (BCF) - L/kg ww
852.9 L/kg ww

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 12 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 12
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Koc at 20°C
3 222.28

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 2.04 µg/L (2)
Intermittent releases (freshwater) 10.2 µg/L (2)
Marine water 204 ng/L (2)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 10 mg/L (2)
Sediment (freshwater) 665 µg/kg sediment dw (2)
Sediment (marine water) 66 µg/kg sediment dw (2)
Hazard for Air
Air No hazard identified (2)
Hazard for Terrestrial Organism
Soil 134 µg/kg soil dw (2)
Hazard for Predators
Secondary poisoning 20 mg/kg food (2)

Short–term toxicity to fish

Study results
  • 10 studies submitted
  • 10 studies processed
P/RResults
LC50 (4 days) 280 - 57 000 µg/L [8]
EC50 (4 days) 179 µg/L [2]
LL50 (4 days) 18 - 42 mg/L [4]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 4 6
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
LC50 for freshwater fish
18 mg/L

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 6 studies submitted
  • 6 studies processed
P/RResults
EC50 (48 h) 307 - 100 000 µg/L [6]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 6
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 / LC50 for freshwater invertebrates
1.02 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to aquatic algae and cyanobacteria

Study results
  • 6 studies submitted
  • 4 studies processed
P/RResults
EC50 (4 days) 74 mg/L [2]
EC50 (48 h) 494 µg/L [2]
NOEC (4 days) 9.1 - 37 mg/L [4]
NOEC (48 h) 247 µg/L [2]
LOEC (48 h) 494 µg/L [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 6
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 for freshwater algae
1.64 mg/L
EC10 or NOEC for freshwater algae
880 µg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Sediment toxicity

Data not provided by the registrant

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Data not provided by the registrant

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 3.52 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: Hazard unknown (no further information necessary)
Acute /short term: Hazard unknown (no further information necessary)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: (High hazard (no threshold derived)) -
Acute /short term: (High hazard (no threshold derived)) -
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 870 µg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: Hazard unknown (no further information necessary)
Acute /short term: Hazard unknown (no further information necessary)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 500 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: (High hazard (no threshold derived)) -
Acute /short term: (High hazard (no threshold derived)) -
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 500 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Bioaccumulation potential:
Low bioaccumulation potential

Acute toxicity

Study results
oral
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
oral
Studies with data
Key study
Supporting study
Weight of evidence 4
Other
Data waiving
no waivers
inhalation
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
dermal
  • 2 studies submitted
  • 2 studies processed
P/RResults
LD50 5 000 mg/kg bw (rabbit) [2]
M/CInterpretations of results
Not classified [2]

dermal
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route:
No adverse effect observed LD50 3 320 mg/kg bw
Dermal route:
No adverse effect observed LD50 5 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
Adverse effect observed (irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
Adverse effect observed (sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 6 studies submitted
  • 2 studies processed
P/RResults
NOAEL (rat): 300 - 1 000 mg/kg bw/day [4]

Type of Study provided
Study data: oral
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: inhalation
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route - systemic effects:
No adverse effect observed NOAEL 300 mg/kg bw/day (subacute, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 6
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Study data: in vivo
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)

Carcinogenicity

Data not provided by the registrant

Toxicity to reproduction

Study results
Study data: reproduction
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: developmental
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 1 000 mg/kg bw/day (subacute, rat)
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 300 mg/kg bw/day (subacute, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant