Registration Dossier

Toxicological information

Sensitisation data (human)

Currently viewing:

Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
other: worker exposure
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Summary data was available for review

Data source

Reference
Reference Type:
secondary source
Title:
Skin Sensitisation Properties of Trimethoxyvinylsilane (CAS No. 2768-02-7) – Experience in Humans
Author:
Momentive
Year:
2013
Report Date:
2013

Materials and methods

Type of sensitisation studied:
skin
Study type:
other: review of worker medical data
Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Type of population:
occupational
Ethical approval:
not specified

Results and discussion

Results of examinations:
Trimethoxyvinylsilane is manufactured in a plants running a 5 shift process on approximately 300 days a year.

Over the course of 18 years 18 people have been in contact with the manufacturing process continuously without any indication of sensitization. An additional 24 people had been in contact with the substance during a 2 shift operational function. There is no evidence of any potential sensitization in the health files of all those individuals over the full manufacturing time.

Applicant's summary and conclusion

Conclusions:
There is no evidence of any potential sensitization in the health files of all those individuals exposured top trimethoxyvinylsilane over many years of manufacturing.