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EC number: 220-449-8
CAS number: 2768-02-7
Challenge Phase: The 10%
formulation of the hydrolysis product in acetone applied to 20 sites
induced one moderate and 19 slight dermal reactions at the 24-hour
observation. Only six sites displayed slight reactions at the 48-hour
evaluation. On the vehicle (acetone) control sites, 12 had slight
reactions at 24-hours post-exposure and a single site had a slight
reaction present at 48 hours. For the Negative Control-I Group animals,
the 10% hydrolysis product solution induced six slight dermal reactions
at both the 24 and 48-hour observation. Two of the vehicle control sites
on the Negative Control-I Group animals were noted with slight dermal
reactions at the 24-hour observation. All irritation completely subsided
by 48 hours. The positive control material, 0.1% dinitrochlorobenzene
(DNCB), induced six slight, two moderate and two severe reactions at 24
hours after challenge dosing. By 48 hours, the responses had increased
to two slight, six moderate and Mo severe reactions. In addition, eschar
was present at all sites at 48 hours post-exposure. Yellow staining was
observed for all positive control sites at both 24 and 48 hours. There
were no skin reactions present on the vehicle control animals treated
with 80% ethanol.
Rechallenge Phase: There were 20
very slight reactions for Test Group guinea pig sites rechallenged with
10% hydrolysis product in acetone at 24 hours. By 48 hours, the number
so affected had fallen to eight. Fifteen very slight reactions were
observed for sites rechallenged with 100% acetone. Irritation completely
subsided for all sites dosed with 100% acetone by 48 hours
post-exposure. All sites rechallenged with 10% hydrolysis product had
slight reactions noted at 24 hours for the Negative Control-Il Group.
Seven of the ten sites had slight dermal reactions at the 48-hour
observation. Eight of the vehicle control sites on the Negative
Control-II Group were noted with slight dermal reactions at 24 hours.
Irritation completely subsided for all but two sites with slight
reactions at 48 hours.
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