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EC number: 220-449-8
CAS number: 2768-02-7
Table 1: Results of the activated sludge respiration inhibition
Loading rate (mg/L)
Oxygen conc. at start (mg O2/L)
Oxygen consumption (mg O2/L/h)
Trichloro(vinyl)silane replicate (1)
Trichloro(vinyl)silane replicate (2)
Toxicity to microorganisms: ASRI
3-hour EC50 >100 mg/L (loading rate) (OECD 209), read-across
from a structurally-related substance.
An activated sludge respiration
inhibition 5-hour EC10 value of 1.1 ml/L (equivalent to 1.03
g/L based on a density of 0.94 g/cm3, Pseudomonas putida) based
on oxygen consumption/respiration inhibition was determined for
trimethoxy(vinyl)silane (CAS 2768-02-7; EC No. 220-449-8) using a
relevant test method and in compliance with GLP (Evonik 1993). The
result is considered to be reliable but is not used as key study because
(i) the study is a 5-hour study instead of the recommended 16 hour
growth inhibition type test recommended in ISO 10712 Test Method, (ii)
the study uses an emulsifier (nonylphenol ethoxylate) to improve
solubility of the test substance, and (iii) no reference substance was
used during the study.
Other results are available for
the registered substance in secondary sources to which reliability
cannot be assigned; bacterial respiration inhibition values of >2500
mg/L (Chandra, 1997) and 3-h NOEC of =1000 mg/L were reported for the
substance (Bennet, 2001).
Therefore, good quality data
for the analogous substance trichloro(vinyl)silane (CAS 75-94-5; EC No.
200-917-8), have been read across. The submission substance,
trimethoxy(vinyl)silane, hydrolyses very rapidly in contact with water
to form vinylsilanetriol (CAS 143-48-6) and methanol (CAS 67-56-1; EC
No. 200-659-6). The read-across substance, trichloro(vinyl)silane, also
hydrolyses very rapidly in contact with water to form vinylsilanetriol
and hydrogen chloride, which rapidly dissolves in water to form
hydrochloric acid (CAS 7647-01-0; EC No. 231-595-7). Both substances
therefore hydrolyse very rapidly and form the same silanol hydrolysis
product; vinylsilanetriol. In view of the very rapid hydrolysis of the
registered substance, it is the silanol hydrolysis product that is
relevant for environmental risk assessment.
Methanol does not have
adverse effects on microorganisms (OECD 2004).
Hydrochloric acid is not
expected to have adverse effects on microorganisms in a sewage
treatment plant, where the pH is maintained within a favourable range.
2768-02-7) and trichloro(vinyl)silane (CAS 75-94-5) are within an
analogue group of substances within which in general, there is no
evidence of significant toxicity to microorganisms.
This group consists of substances
containing a number of different functional groups but specific
read-across is between substances with similar functionality. In this
case, read-across from a substance with different functional group i.e.
trichlorosilanes (Si-Cl) is used for the registered substance,
trimethoxy(vinyl)silane. This is because data available for the
trimethoxysilanes functional group does not contain any substances with
a vinyl side-chain and it was considered important to cover this
structural feature. Both trichloro(vinyl)silane and
trimethoxy(vinyl)silane hydrolyse very rapidly to form the same silanol
hydrolysis product, vinylsilanetriol.
It is therefore considered valid
to read-across the results for trichloro(vinyl)silane (CAS 75-94-5) to
fill the data gap for the registered substance since the source and
target substances generate the same silanol hydrolysis product.
Additional information is given in a supporting report (PFA 2013j)
attached in Section 13.
The table below presents
microorganism toxicity data for substances relevant to
trimethoxy(vinyl)silane (CAS 2768-02-7).
Table: Microorganism toxicity data
available for relevant substances
This is a unique
internal ID code which can be used to identify the reference for the
In the study with
trichloro(vinyl)silane (CAS 75-94-5), an activated sludge respiration
inhibition 3-hour EC50 value of >100 mg/L was determined in a
study conducted in accordance with OECD Test Guideline 209 and in
compliance with GLP.
OECD (2004): SIDS Initial
Assessment Report for SIAM 19, Berlin, Germany, 18-20 October 2004,
Methanol, CAS 67-56-1
PFA (2013j). Peter Fisk
Associates, STP Microorganism toxicity Main Analogue Group report,
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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