Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-449-8 | CAS number: 2768-02-7
Endpoint summary
Administrative data
Description of key information
Additional information
Reliable short-term toxicity tests results are available for freshwater fish (Oncorhynchus mykiss), invertebrates (Daphnia magna) and algae (Pseudokirchneriella subcapitata) for the registered substance, trimethoxy(vinyl)silane (CAS 2768-02-7; EC No. 220-449-8). The relevant short-term values are:
Fish: LC50 (96 h): 137 mg/L expressed in terms of concentration of the hydrolysis product, vinylsilanetriol.
Daphnia: EC50 (48 h): 121 mg/L expressed in terms of concentration of the hydrolysis product, vinylsilanetriol.
Algae: EC50 (72 h): >64 mg/L; NOEC: =64 mg/L expressed in terms of concentration of the hydrolysis product, vinylsilanetriol.
Long-term data are available with invertebrates (Daphnia magna):
21-day NOEC: 20 mg/L expressed in terms of concentration of the hydrolysis product, vinylsilanetriol.
The very rapid hydrolysis of trimethoxy(vinyl)silane (CAS 2768-02-7) (half-life 0.1 h at pH 7 and 20-25°C) means it is likely that the test organisms in each test were exposed primarily to the hydrolysis products, vinylsilanetriol (CAS 143-48-6) and methanol (CAS 67-56-1; EC No. 200-659-6).
There are no reliable microorganism toxicity data available for trimethoxy(vinyl)silane (CAS 2768-02-7), therefore good quality data for the structurally-related substance, trichloro(vinyl)silane (CAS 75-94-5; EC No. 200-917-8)), have been read across. Both substances share the same silanol hydrolysis product, vinylsilanetriol. The other hydrolysis products are methanol and hydrogen chloride / chloride salts (CAS 7647-01-0; EC No. 231-595-7) respectively.
Refer to IUCLID Section 6 endpoint summary (CSR Section 7.0) for further discussion of the approach to chemical safety assessment and justification for read-across.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
