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Environmental fate & pathways

Hydrolysis

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Endpoint:
hydrolysis
Data waiving:
study technically not feasible
Justification for data waiving:
the study does not need to be conducted because the substance is highly insoluble in water
Endpoint:
hydrolysis
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
Episuite/Hydrowin program was used to calculate the half-lives of the substance. The program was developed by the US Environmental Prevention Agency's Office of Pollution Prevention Toxics and Syracuse Research Corporation. Informartion about the the program is publically available.
Principles of method if other than guideline:
HYDROWIN v2.00 from EPIsuite, copyright by US Environmental Protection Agency
Preliminary study:
Due to the Hydrowin data set it can be concluded that the substance is hydrolytically stable.
Transformation products:
not measured
Key result
Remarks on result:
hydrolytically stable based on preliminary test
Remarks:
Result is based on calculation
Conclusions:
Due to the result based on the HYDROWIN v2.00, the substance can be as assessed as hydrolytically stable.

Description of key information

The registration substance bears no functional groups which can be cleaved by hydrolysis, except a cyclic amide structure. For these groups a calculation with EPIWIN shows that hydrolytical cleavage is unlikely.


In addition a study can technically not be conducted as the registration substance is highly insoluble in water.

Key value for chemical safety assessment

Additional information