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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: case report
Adequacy of study:
supporting study
Study period:
1985
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Case report

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
1985
Reference Type:
publication
Title:
Unnamed
Year:
1987

Materials and methods

Study type:
other: Case report
Endpoint addressed:
skin sensitisation
Principles of method if other than guideline:
no guideline required
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4,4'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[2,4-dihydro-5-methyl-2-(p-tolyl)-3H-pyrazol-3-one]
EC Number:
239-898-6
EC Name:
4,4'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[2,4-dihydro-5-methyl-2-(p-tolyl)-3H-pyrazol-3-one]
Cas Number:
15793-73-4
Molecular formula:
C34H28Cl2N8O2
IUPAC Name:
4,4'-[(3,3'-dichlorobiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis[5-methyl-2-(4-methylphenyl)-2,4-dihydro-3H-pyrazol-3-one]

Method

Subjects:
- Number of subjects exposed: 1
- Sex: female
- Age: 49
- Demographic information: cleaning personal
- Known diseases: sensitisation to rubber
Route of exposure:
dermal
Reason of exposure:
intentional, occupational
Exposure assessment:
not specified

Results and discussion

Clinical signs:
symptoms: sharply defined glove dermatitis after wearing of PVC gloves



Any other information on results incl. tables

Pigment tested at 2% and 0.5% in petrolatum, result: 2+ reaction (both concentrations)

Patch test with glove: weak reaction

Other ingredients: negative

10 control tests with pigment (2% in petrolatum): negative

Applicant's summary and conclusion

Executive summary:

One case report documents the sensitisation to Irgalite Orange F2G (Pigment Orange 34) after the use of PVC gloves.