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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
29 March 2010 - 2 April 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Specific details on test material used for the study:
4,4'-oxydianiline
4,4'-diaminodiphenyl ether
CAS 101-80-4
Key result
Water solubility:
0.048 g/L
Temp.:
20 °C
pH:
>= 6.49 - <= 6.71
Remarks on result:
other: determined to be 0.048 ± 0.004 g/L (95 % confidence interval) at 20 °C ± 1 °C using the shake-flask method
Details on results:
Calibration

The calibration curves were prepared on each analytical occasion. Concentrations of the calibration samples were 0.02, 0.05, 0.2, 0.5, 2, 5 and 10 test item ug /ml.
The 4,4-Diaminodiphenylether concentrations were calculated with the help of the calibration equations given in Table 2 (see below)

 Table 2. Regression data

Analytical occasion

Constant

X Coefficient

R. Squared

31 March 2010

 

-218

128898

1.000

1April 2010

 

-574

131257

1.000

2 April 2010

 

-622

128645

1.000

 

Measured concentrations of the test substance are summarised in Table 3. The repeatability of the determination was <15 %, and thus within the range required by the guidelines.

 

Measured concentration after 24 hours (jig/ml)

Measured concentration after 48 hours (jig/ml)

Measured concentration after 72 hours (jig/ml)

45.1

49.7

42.7

52.4

45.4

47.0

51.0

44.1

50.2

Mean: 49.5

Mean: 46.4

Mean: 46.6

 

Table 4. Measured pH values

Measured pH values after 24 hours

Measured pH values after 48 hours

Measured pH values after 72 hours

6.51

6.62

6.65

6.45

6.50

6.57

6.49

6.57

6.71

Conclusions:
The water solubility of 4,4-Diaminodiphenylether was determined to be 0.048 ± 0.004 g/L (95 % confidence interval) at 20 °C ± 1 °C using the shake-flask method. According to this result, the test item is considered slightly soluble (0.1-100 mg/L)
Executive summary:

The water solubility of 4,4-Diaminodiphenylether was determined to be 0.048 ± 0.004 g/L (95 % confidence interval) at 20 °C ± 1 °C using the shake-flask method.

Description of key information

The water solubility of the test item was assessed using the shake-flask method.

The water solubility of 4,4-Diaminodiphenylether was determined to be 0.048 ± 0.004 g/L (95% confidence interval) at 20 °C ± 1 °C.

Key value for chemical safety assessment

Water solubility:
0.048 g/L
at the temperature of:
20 °C

Additional information