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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
01 February 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
determination of fibre length and diameter distributions
Type of distribution:
volumetric distribution
Specific details on test material used for the study:
4,4'-oxydianiline
4,4'-diaminodiphenyl ether
CAS 101-80-4
Key result
Percentile:
D50
Mean:
100 µm
Remarks on result:
other: The inhalable fraction is defined as the mass fraction of particles which can be inhaled by nose or mouth.(migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.)
No.:
#1
Size:
100 µm
Distribution:
3.01 %
Remarks on result:
other: The proportion of test material having an inhalable particle size of less than 100 µm was determined to be 3.01%.

The results of the sieving procedure are shown in the following table:

 

Measurement

Result

Mass of test material transferred to sieve

15.94g

Mass of test material passed through sieve

0.48g

Proportion of test material <100 |jm

3.01%

Conclusions:
The proportion of test material having an inhalable particle size of less than 100 µm was determined to be 3.01%. The substance is therefore not consdered to pose a hazard by inhalation based on this amount.
Executive summary:

The proportion of test material having an inhalable particle size of less than 100 µm was determined to be 3.01%. The substance is therefore not considered to pose a hazard by inhalation based on this amount.  Furthermore, given the form of the substance imported into the EU, and the inhalable fraction assessed, it is unlikely that the substance will also pose a respirable dust hazard.

Description of key information

The particle size distribution of the substance 4,4'-Oxydianiline was determined according to the OECD Guideline 110, under GLP conditions.

The proportion of test material having an inhalable particle size of less than 100 µm was determined to be 3.01%.  The substance is therefore not consdered to be hazardous by inhalation based on this amount.

Additional information