Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-375-5 | CAS number: 81-77-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Carcinogenicity
Administrative data
Description of key information
rats, oral in diet: negative; rats, subcutaneous: negative (Umeda 1956 / cited in WHO report 1974)
rats, oral in diet: negative (Nothdurft 1961)
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Study duration:
- chronic
- Species:
- rat
- Quality of whole database:
- All available studies pre-date GLP and OECD testing guidelines. Insufficient details are available.
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Species:
- rat
- Quality of whole database:
- All available studies pre-date GLP and OECD testing guidelines. Insufficient details are available.
Justification for classification or non-classification
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008:
The available data does not give rise of concern for carcinogenicity.
As a result the substance is not considered to be classified for carcinogenicity under Regulation (EC) No. 1272/2008.
Additional information
There are three tests which examined the carcinogenic potential of the test substance, but data is either only available from a secondary source or it is not reported in the detail currently demanded by OECD testing guidelines (Nothdurft 1961).
In the first study 21 rats were fed with 0.1% of the test substance (no data on purity) in the diet for 184 days. The animals were checked for tumours and no increased tumour incidence was observed. 8 rats which survived for more than 400 days (432-683) showed no abnormalities (Umeda 1956, cited in WHO report 1974).
Additionally, 12 rats received monthly subcutaneous injections of an aqueous suspension of the test substance (2 mL of 2.5% suspension; no data on purity) for their whole lives. No tumours were seen at the site of injection (Umeda 1956, cited in WHO report 1974).
In the third test by Nothdurft (1961) which was cited in the WHO report of 1974 rats received the test substance (no data on purity) at 0.1% and 1% in their diet. The increase in tumour incidence was observed over their life-span. 11 animals died before the end of the experiment in the 1% group. No increase of the tumour incidence occurred compared to historical controls. No data of the 0.1% group was available.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
